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A disease of the nervous system characterized by a progressive dementia that leads to profound impairment in cognition and behavior. Dementia occurs in a number of brain diseases where the impairment in cognitive abilities represents a decline from…

Cells within a tumor that possess the capacity to self-renew and cause the heterogeneous lineages of cancerous cells that comprise the tumor. Cancer stem cells (CSCs) typically represent a small percentage of all cells in a tumor (rarely more than…

A genome-engineering technique that allows precise targeting of specific stretches of genetic code and editing of DNA at designated locations. The CRISPR/Cas9 system has been used as a general tool to engineer the genomes of many different…

An organism that has had its genetic material manipulated or altered in a laboratory setting through the use of genetic or genomic engineering techniques. Genetically modified organisms (GMOs) are microorganisms, plants, or animals that have been…

An experience of discomfort, primarily associated with tissue damage. Pain involves somesthetic sensations that are generally unpleasant and often cause suffering or distress. Pain (see illustration) is more complex than other sensory systems, such…