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A common medicine used to relieve mild to moderate pain and reduce fever. Acetaminophen (N-acetyl-p-aminophenol), or paracetamol, is a white crystalline compound with the molecular formula C8H9NO2 (Fig. 1). It is a member of the aniline family of…

Natural and artificial substances in the atmosphere that affect human health or well-being, or the well-being of any other organisms in the environment. Air pollution also applies to situations in which contaminants affect structures and artifacts…

A disease of the nervous system characterized by a progressive dementia that leads to profound impairment in cognition and behavior. Dementia occurs in a number of brain diseases where the impairment in cognitive abilities represents a decline from…

A member of a group of organic compounds that can be considered as derived from ammonia by replacement of one or more hydrogens by organic functional groups. Generally amines are bases of widely varying strengths, but a few that are acidic are…

A conductor whose purpose is to emit and/or receive electromagnetic waves using the bulk oscillations of electric charges within the conductor. The conduction electrons in antennas are free to move throughout the conductor. The electrons form a bulk…

An ongoing current event in which a large number of living species are threatened with extinction or are going extinct because of environmentally destructive human activities. The Earth is presently in the midst of a mass extinction event. In the…

The subfield of computer science concerned with understanding the nature of intelligence and constructing computer systems capable of intelligent behavior. Many activities, such as perception, learning, planning, natural language, and understanding,…

An analytical technique for determining the composition of a sample in terms of the chemical elements present and their quantities or concentrations. Unlike other methods of elemental analysis, however, the sample is decomposed into its constituent…

A neurodevelopmental condition that impairs the way that a person relates to and communicates with other people. Persons with autism have difficulties with social communication and interaction. They also can have unusual behaviors, such as…

The ongoing lower level of species extinction intensity occurring between episodes of mass extinctions. Extinction is a normal part of the history of life. Out of every 100 species that have ever lived on Earth, 99 are no longer in existence.…

Any of the cells within a tumor that possess the capacity to self-renew and cause the heterogeneous lineages of cancerous cells that comprise the tumor. Cancer stem cells (CSCs) typically represent a small percentage of all cells in a tumor (rarely…

A poisonous colorless, odorless, tasteless gas (CO), resulting from the incomplete combustion of carbon-containing materials. Carbon monoxide (Fig. 1) is an indoor hazard causing hundreds of deaths annually, and it is one of the six major air…

Any clouding or opacity of the crystalline lens of the eye. Loss of the transparency of the lens (see illustration) prevents the normal passage of light onto the light-sensitive retina at the back of the eye and thus a loss of visual ability.…

Cameras in mobile phones or smartphones that can capture images and videos.The cellphone, the world’s favorite must-have gadget, has been with us for nearly a half-century, while experiencing continuous and often phenomenal improvements. Much of the…

Light emitted by a high-speed charged particle when the particle passes through a transparent, nonconducting, solid material at a speed greater than the speed of light in the material. The emission of Cerenkov radiation—also spelled Cherenkov—is…

The attractive force that holds atoms or ions together. Chemical bonds are very strong. To break one bond in each molecule in a mole of material typically requires an energy of many tens of kilocalories.It is convenient to classify chemical bonding…

The administration of chemical substances for the treatment of disease, especially cancer, or for the prevention of aberrant growth of cells or tissues (neoplasms). In general, chemotherapy is the use of chemicals to treat any disease, but the term…

A chemical element, Cl, atomic number 17 and atomic weight 35.453. Chlorine exists as a greenish-yellow gas at ordinary temperatures and pressures (see illustration). It is second in reactivity only to fluorine among the halogen elements, and hence…

The internal structures and processes that are involved in the acquisition and use of knowledge, including sensation, perception, attention, learning, memory, language, thinking, and reasoning. The mental processes and behaviors that constitute…

A psychotherapy with roots in both cognitive science and behavioral science. Cognitive-behavioral therapy (CBT) is the most widely used evidence-based psychotherapeutic practice for a variety of mental health disorders, including anxiety, depression…

A branch of computer science that deals with the theory and techniques of computer-generated images. Computers produce images by analyzing a collection of dots, or pixels (picture elements). Computer graphics is used to enhance the transfer and…

The extraction and refining of copper (Cu) from its ores. About 18 million metric tons per year of copper metal is produced from the mining and processing of copper ores, typically containing only about 1% Cu. About 80% of the world's primary copper…

The response of corals to environmental stress in which they eject the single-cell algae that live within the transparent coral tissue, making the white coral skeleton visible. Corals (Fig. 1) are animals that live in a partnership (symbiosis) with…

A genome-engineering technique that allows precise targeting of specific stretches of genetic code and editing of DNA at designated locations. The CRISPR/Cas9 system has been used as a general tool to engineer the genomes of many different…

A syndrome characterized by a generalized decline in cognition that is severe enough to cause functional impairment in daily activities. Dementia is a term used to describe a collection of symptoms of severe cognitive decline. Individuals suffering…

The capture, processing, transmission, and storage of images in electronic form. Digital photography differs from film photography in that images are captured and recorded as electronic files rather than as recognizable images on a light-sensitive…

The interaction of the behavior and ecology of hosts with the biology of pathogens as relating to the impact of diseases on populations. Although human diseases have been studied from an ecological perspective for centuries, diseases in plant and…

A radar system used to measure the relative velocity of targets and their position. The operation of these systems is based on the fact that the Doppler frequency shift in the target echo is proportional to the radial component of target velocity.…

A general term referring to a system or part of a system of conducting parts and their interconnections through which electric currents are intended to flow. A circuit is made up of a voltage source along with active and passive elements, as well as…

The measure of the opposition that an electrical circuit presents to the passage of a current when a voltage is applied. In quantitative terms, electrical impedance is the complex ratio of the voltage to the current in an alternating-current (ac)…

The ability of a material to resist or allow the flow of electrical current. Material properties largely determine the resistance and conductance—quantified by electrical resistivity and conductivity—of a given object, such as a circuit or…

The measures of a material's opposition to the flow of electricity and a material's ability to conduct electricity, respectively. Resistivity quantifies resistance, which is a material's opposition to the flow of electrons (an electric current or…

The process in which an electron, which has been excited from the valence band to the conduction band of a semiconductor, falls back into an empty state in the valence band, which is known as a hole. When atoms come together to form a crystal, the…

A term commonly associated with both behaviors and states of mind (known as feelings) that are not under the control of reason and disturb the flow of consciously directed behavior. Emotions influence human thinking and behavior (Fig. 1), and they…

A condition characterized by the paroxysmal recurrence of transient, uncontrollable episodes of abnormal neurological or mental function (or both). "Epilepsy" generally refers to the medical condition of recurrent, unprovoked seizures, and the term…

An interdisciplinary science area that is concerned with modeling aspects of natural evolution in order to solve real-world problems of optimization. Living organisms, as well as those that are long extinct, demonstrate optimized complex behavior at…

Typically, an aquatic vertebrate with scales, gills, and paired fins. Fishes (Fig. 1) are found throughout the world's waterways, from saltwater oceans to freshwater streams and ponds. About 35,000 species of fishes have been described to date. Many…

In thermodynamics, the amount of useful work that can be extracted from a closed thermodynamic system. The Helmholtz free energy applies to a process that takes place at a constant temperature T (isothermal process). The Gibbs free energy applies to…

A biological organism whose genetic material has been manipulated artificially through genetic or genomic editing techniques. In contrast to the long history of artificial selection (domestication), in which humans selectively breed organisms to…

A space-traversing unmanned vehicle which contains the means for controlling its flight path and that delivers an explosive warhead with high accuracy. Various kinds of missiles are guided in the sense that they can aerodynamically adjust after…

Pathologies or aberrations in structure or function of blood cells or the blood-clotting mechanism. Hematologic disorders affect the blood and blood-forming organs. Although many diseases and abnormal conditions may be reflected by the blood and its…

A vacant electron energy state near the top of an energy band in a solid. A hole, or more formally an electron hole, represents the absence of an electron where one could exist as part of an atom or within a crystal structure (an atomic lattice)…

An applied science and technology concerned with the mechanical properties and practical uses of liquids. The physical description of fluids in motion is based upon the conservation laws of mass, momentum, and energy. The mathematical statement of…

The process of tissue death (necrosis) resulting from a failure of blood supply and lack of oxygen (anoxia) reaching the tissue's cells. The usual cause of infarction is occlusion (blockage or closing) of an artery by a thrombus (blood clot; see…

The entrance, growth, and multiplication of a microorganism or pathogen in the body of a host. Infection may or may not result in the establishment of a disease process, depending on many variables including the pathogen involved, the health of the…

A species translocated from one region or continent to another outside its normal range, particularly when the translocation is the result of human activity (intentional or otherwise). Many thousands of species, including animals, plants, fungi,…

Fundamental laws dealing with electric currents at junctions and voltages around any loop within a network. Also known as Kirchhoff's circuit laws, the laws were first described by German physicist Gustav Kirchhoff in 1845. The laws are divided into…

A salt or ester of lactic acid (CH3CHOHCOOH). In lactates, the acidic hydrogen of the carboxyl group has been replaced by a metal or an organic radical. Lactates are optically active, with a chiral center at carbon 2. The two optical isomers of a…

A disease caused by members of the protozoan genus Plasmodium (a widespread group of protists that parasitize the human liver and red blood cells) and transmitted by the bite of the female Anopheles mosquito. Malaria is a serious mosquito-borne…

Impaired health caused by a dietary deficiency, excess, or imbalance. To support human life, energy (from fat, carbohydrate, and protein), water, and more than 40 different food substances must be obtained from the diet in appropriate amounts.…