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A distinct phylum of helminths (parasitic worms), commonly known as the spiny- or thorny-headed worms. The phylum Acanthocephala comprises three classes: Archiacanthocephala, Palaeacanthocephala, and Eoacanthocephala (a suggested fourth class,…

A viral disease of humans caused by the human immunodeficiency virus (HIV), which attacks and compromises the body's immune system. Individuals infected with the human immunodeficiency virus (HIV) proceed through a spectrum of stages that ultimately…

A genus of gram-negative, immotile and nonspore-forming, oval to rod-shaped, often pleomorphic bacteria which occur as parasites or pathogens in mammals (including humans), birds, and reptiles. They are facultatively aerobic, capable of fermenting…

A heterogeneous collection of bacteria with diverse ecologies and physiologies. The initial definition was based on their branching filamentous cellular morphology during a stage of the growth cycle. The name actinomycete means “ray fungus,” and for…

Habituation to a specific practice, such as drinking alcoholic beverages or using drugs (for example, heroin, cocaine, or amphetamines), and disorders characterized by the chronic use of a drug, alcohol, or similar substance. Addiction and addictive…

One of the four fundamental operations of arithmetic and algebra. The symbol + of addition is thought to be a ligature for “et,” used in a German manuscript of 1456 to denote addition. Its first printed appearance is in Johann Widman's Behennede und…

A type of defective virus particle in which part of the genetic material of papovavirus SV40 is encased within an adenovirus protein coat (capsid). Human adenoviruses require human cells for their propagation; however, papovavirus SV40 can serve as…

A family of double-stranded DNA viruses, collectively known as adenoviruses, which are icosahedrally symmetric, usually found in the respiratory tract of the host species, and often associated with respiratory diseases. Members of the Adenoviridae…

Malfunctions of the paired adrenal glands. The adrenal glands can have congenital defects and can be damaged by infections and destructive tumors. Anencephaly, that is, gross underdevelopment of the brain in fetal life, leads to hypoplasia of the…

A bacterial genus in the family Vibrionaceae comprising oxidase-positive, facultatively anaerobic, monotrichously flagellated gram-negative rods. The mesophilic species are A. hydrophila, A. caviae, and A. sobria; the psychrophilic one is A.…

Aeronomy concentrates on the regions above the tropopause or upper part of the atmosphere. The region of the atmosphere below the tropopause is the site of most of the weather phenomena that so directly affect all life on the planet; this region has…

Any of a group of secondary metabolites produced by the common molds Aspergillus flavus and A. parasiticus that cause a toxic response in vertebrates when introduced in low concentration by a natural route. The group constitutes a type of mycotoxin.…

A highly fatal insect-borne viral disease of horses and mules, and a mild, subclinical disease in donkeys and zebras. African horse sickness occurs in sub-Saharan Africa, but incursions outside Africa have been documented. Dogs may be affected by…

A variety of chalcedonic quartz that is distinguished by the presence of color banding in curved or irregular patterns (Fig. 1). Most agate used for ornamental purposes is composed of two or more tones or intensities of brownish-red, often…

An age-contingent reduction in physiological function and activity, with a concomitant increase in mortality rate and a diminution in reproductive rate. Aging is the process of becoming older, which is influenced by genetic and environmental…

A sodium-rich plagioclase feldspar mineral whose composition extends over the range Ab100An0 to Ab90An10, where Ab (= albite) is NaAlSi3O8 and An (= anorthite) is CaAl2Si2O8 (see illustration). Albite occurs in crustal igneous rocks as a major…

The repeated and/or excessive use of alcohol (ethanol) that continues despite negative physical, psychiatric, or social consequences. Alcoholism is characterized by consuming alcohol more often, in larger amounts, or over longer periods than…

The branch of mathematics dealing with the solution of equations. These equations involve unknowns, or variables, along with fixed numbers from a specified system (Fig. 1). The origins of algebra were based on the need to develop equations that…

The study of zero sets of polynomial equations. Examples are the parabola y − x2 = 0, thought of as sitting in the (x, y)-plane, and the locus of all points (t, t2, t3, t4), which is defined by Eqs. (1), 1 in the coordinate space with coordinates w,…

Light emissions in the upper atmosphere from elemental lithium, potassium, and especially sodium. These alkali metals are present in the upper atmosphere at altitudes from about 50 to 62 mi (80 to 100 km) and are very efficient in resonant…

Altered reactivity in humans and other animals to allergens (substances foreign to the body that trigger an allergic response) induced by exposure through injection, inhalation, ingestion, or skin contact. An allergy (or allergic reaction; Fig. 1)…

A mineral of composition KAl3(SO4)2(OH)6. Alunite occurs in white to gray rhombohedral crystals or in fine-grained, compact masses. It has a hardness of 4 and a specific gravity of 2.6–2.8.Alunite is produced by sulfurous vapors on acid volcanic…

A disease of the nervous system characterized by a progressive dementia that leads to profound impairment in cognition and behavior. Dementia occurs in a number of brain diseases where the impairment in cognitive abilities represents a decline from…

An alloy of mercury. Practically all metals will form alloys, or amalgams, with mercury, with the notable exception of iron. Amalgams are used as dental materials (see illustration), in the concentration of gold and silver from their ores, and as…

Most commonly, a generic name for all fossil resins, although it has been restricted by some to refer only to succinite, the mineralogical species of fossil resin that includes most of the Baltic Coast deposits. Resins generally are complex mixtures…

The transparent purple to violet variety of the mineral quartz. Although quartz is perhaps the commonest gem mineral known, amethyst is rare in the deep colors that characterize fine quality. Amethyst is usually colored unevenly and is often heated…

Any of the organic compounds possessing one or more basic amino groups and one or more acidic carboxyl groups. Of the more than 80 amino acids that have been found in living organisms, approximately 20 serve as the building blocks for proteins.…

Determination of the relative or absolute age of materials or objects by measurement of the degree of racemization of the amino acids present. With the exception of glycine, the amino acids found in proteins can exist in two isomeric forms called d-…

A stimulating drug that affects the brain and the body. Amphetamine is a stimulant of the central nervous system. Chemically, amphetamine is a racemic mixture of the l and d isomers of α-methyl-β-phenethylamine (see illustration). The l isomer has…

A disorder characterized by the accumulation of an unusual extracellular fibrous protein (amyloid) in the connective tissue of the body. The deposition of amyloid may be widespread, involving major organs and leading to serious clinical…

An infection caused by anaerobic bacteria (organisms that are intolerant of oxygen). Most anaerobic infections are mixed, involving more than one anaerobe and often aerobic or facultative bacteria as well.Bacteria InfectionAnaerobes are prevalent…

A mineral with a framework structure in which all the aluminosilicate tetrahedral vertices are linked, thus allying it to the feldspars, feldspathoids, and zeolites. The structure is cubic, space group Ia3d, a = 1.371 mm. Its formula is…

Total variation in experimental data is partitioned into components assignable to specific sources by the analysis of variance. This statistical technique is applicable to data for which (1) effects of sources are additive, (2) uncontrolled or…

A branch of mathematics in which algebra is applied to the study of geometry. Because algebraic methods were first systematically applied to geometry in 1637 by the French philosopher-mathematician René Descartes, the subject is also called…

A framework for solving a problem. The analytic hierarchy process is a systematic procedure for representing the elements of any problem. It organizes the basic rationality by breaking down a problem into its smaller constituents and then calls for…

A disease of mammals caused by a specialized group of gram-negative bacteria in the order Rickettsiales, family Anaplasmataceae, genus Anaplasma. Anaplasma is an obligate intracellular parasite that infects erythrocytes (red blood cells) of…

A nesosilicate mineral, composition Al2SiO5, crystallizing in the orthorhombic system. It occurs commonly in large, nearly square prismatic crystals. The variety chiastolite has inclusions of dark-colored carbonaceous material arranged in a regular…

A plagioclase feldspar with composition Ab70An30 to Ab50An50 (Ab = NaAlSi3O8; An = CaAl2Si2O8). Andesine occurs primarily in igneous rocks, often in a glassy matrix as small, chemically zoned, lathlike crystals known as microlites. The rock types…

A typical volcanic rock erupted from a volcano associated with convergent plate boundaries. The process of subduction, which defines convergent plate boundaries, results in the sinking of oceanic lithosphere beneath either oceanic lithosphere or…

Synthetic manufactured drugs derived from the male sex hormone testosterone. Androgenic-anabolic steroids, often termed simply as anabolic steroids, are artificially produced testosterone variants. They can provide a number of medical benefits when…

A class of steroid hormones produced in the testes and adrenal cortex that act to regulate masculine secondary sexual characteristics. The major naturally occurring androgens, such as testosterone, are C-19 steroids (that is, they each contain 19…

A medical condition resulting from a reduction in the total quantity of hemoglobin or of red blood cells in the circulation. Anemia is a disorder marked by significant decreases in hemoglobin concentration and in the number of circulating red blood…

The condition of exhibiting no immune response to an antigen. Anergy is a self-tolerance mechanism in which the immune system shows unresponsiveness following an encounter with receptor-recognized antigens. Typically, lymphocytes (the B and T cells…

Loss of sensation with or without loss of consciousness. There are several ways of producing anesthesia, with the choice dependent on the type of surgery and the medical condition and preference of the patient. Each person responds differently to a…

A localized, abnormal arterial dilation usually caused by a weakening of the vessel wall. Aneurysms are commonly found in the abdominal aorta, intracranial arteries, and thoracic aorta; however, they may also involve the femoral, popliteal, splenic,…

A mineral with the chemical composition PbSO4. Anglesite occurs in white or gray, orthorhombic, tabular or prismatic crystals or compact masses (see illustration). It is a common secondary mineral, usually formed by the oxidation of galena. Fracture…

A mineral with the chemical composition CaSO4. Anhydrite occurs commonly in white and grayish granular masses, rarely in large, orthorhombic crystals (see illustration). Fracture is uneven and luster is pearly to vitreous. Hardness is 3–3.5 on Mohs…

The use of live nonhuman animals for scientific research and experimentation. Animal testing has been a cornerstone of biomedical research, having contributed greatly to the understanding of human biology, to the unraveling of the complex underlying…

A small infectious agent that is unable to replicate outside a living animal cell. Unlike other intracellular obligatory parasites (for example, chlamydiae and rickettsiae), animal viruses contain only one kind of nucleic acid, either…

The carbonate mineral Ca(Fe,Mg)(CO3)2, also commonly containing some manganese. The mineral has hexagonal (rhombohedral) symmetry (see illustration) and has the cation-ordered structure of dolomite. The name is applied only to those species in which…

The calcium-rich plagioclase feldspar with composition Ab0An100 to Ab10An90 (Ab = NaAlSi3O8; An = CaAl2Si2O8), occurring in olivine-rich igneous rocks and rare volcanic ejecta (for example, at Mount Vesuvius, Italy, and Miyakejima, Japan). Hardness…

The name usually given to alkali feldspars which have a chemical composition ranging from Or40Ab60 to Or10Ab90± up to approximately 20 mole % An (Or, Ab, An = KAlSi3O8, NaAlSi3O8, CaAl2Si2O8) and which deviate in one way or another from monoclinic…

A rock composed of 90 vol % or more of plagioclase feldspar. Strictly, the rock is composed entirely of crystals discernible with the eye, but some finely crystalline examples from the Moon have been called anorthosite or anorthositic breccia. Two…

Oxygen-depleted regions in marine environments. The dynamic steady state between oxygen supply and consumption determines the oxygen concentration. In regions where the rate of consumption equals or exceeds the rate of supply, seawater becomes…

The Antarctic Circle is an imaginary line that delimits the northern boundary of Antarctica. It is a distinctive parallel of latitude at approximately 66°30′ south. Thus it is located about 4590 mi (7345 km) south of the Equator and about 1630 mi…

The Antarctic Ocean, sometimes called the Southern Ocean, is the watery belt surrounding Antarctica. It includes the great polar embayments of the Weddell Sea and Ross Sea, and the deep circumpolar belt of ocean between 50 and 60°S and the southern…

A magnesium-rich orthorhombic amphibole with perfect {210} cleavage and a color which varies from white to various shades of green and brown. It is a comparatively rare metamorphic mineral which occurs as slender prismatic needles, in fibrous…

An acute, infectious worldwide zoonotic disease (transmissible to humans) caused by the spore-forming bacterium Bacillus anthracis to which most animals, especially grazing herbivores, are susceptible. Anthrax is a serious, though rare, infectious…

The capability that a bacterium acquires to counteract an inhibitory chemical molecule or compound that was formerly effective in killing it or preventing its growth. Antibiotic resistance in bacteria (Fig. 1) is a hot topic in the media and in…

A fold in layered rocks in which the strata are inclined down and away from the axes. The simplest anticlines (see illustration) are symmetrical, but in more highly deformed regions they may be asymmetrical, overturned, or recumbent. Most anticlines…

A type of drug that inhibits the combination of histamine with histamine receptors. These drugs are termed either H-1 or H-2 receptor antagonists depending on which type of histamine receptor is involved. H-1 receptor antagonists are used largely…

A chemical substance used to destroy or prevent the growth of infectious microorganisms on or in a human or other animal body. An antiseptic is an antimicrobial compound or drug preparation that inhibits the spread and development of harmful…

Apatite is a generic name used to describe calcium phosphates with the simplified formula Ca10(PO4)6X2 (X = F, Cl, OH). Three end members form a complete solid-solution series involving the halide and hydroxyl anions, and these are the species…

A fine-grained, sugary-textured rock, generally of granitic composition; also any body composed of such rock. GraniteThe light-colored rock consists chiefly of quartz, microcline, or orthoclase perthite and sodic plagioclase, with small amounts of…

A hydrous calcium potassium silicate containing fluorine. The composition is variable but approximates to KFCa4(Si2O5)4· 8H2O. It resembles the zeolites, with which it is sometimes classified, but differs from most zeolites in having no aluminum. It…

Programmed cell death triggered by extracellular signals or genetically determined events and carried out by physiological processes within the cell. Apoptosis is one of the major forms of cell death in multicellular organisms (necrosis is the other…

An inflammation of the vermiform appendix. Acute appendicitis is the most common cause of emergency abdominal surgery, occurring in 5–6% of the population of the United States. Although about 80% of the individuals are between 5 and 35 years of age,…

A narrow, elongated tube closed at one end, extending from the cecum (a blind pocket off the first part of the large intestine). The appendix (see illustration), also known as the vermiform appendix, is found in only a few mammals. The size and…

A subsurface zone that yields economically important amounts of water to wells. The term is synonymous with water-bearing formation. An aquifer may be porous rock, unconsolidated gravel, fractured rock, or cavernous limestone. Economically important…

One of three naturally occurring mineral forms of calcium carbonate (CaCO3). The other forms (or polymorphs) are the abundant mineral calcite and the relatively rare mineral vaterite. Still other forms of calcium carbonate are known, but only as…

A number of diseases, including Saint Louis encephalitis, Japanese encephalitis, and various forms of equine encephalitis, which are caused by arthropod-borne viruses (arboviruses). In their most severe human forms, the diseases collectively termed…

A period of geologic time from about 4000 to 2500 million years ago (MYA). During the Archean Eon (Fig. 1) a large percentage of the Earth's continental crust formed, plate tectonics began, very warm climates and oceans existed, and life appeared on…

Defined primarily by climatic rather than latitudinal criteria, arctic islands are those in the Northern Hemisphere where the mean temperature of the warmest month does not exceed 50°F (10°C) and that of the coldest is not above 32°F (0°C).…

The parallel of latitude approximately 66°30′ north of the Equator, or 23.5° from the North Pole. Named for the northern constellation Bear, the Arctic Circle has the same angular distance from the Equator as the inclination of the Earth's axis from…

The Arctic Ocean is an enclosed ocean, connected to the Pacific Ocean through Bering Strait and Bering Sea, and to the Atlantic Ocean through Fram Strait and the Barents, Greenland, and Norwegian seas (see illustration). The Arctic Ocean is the…

The superficial contents of a geometrical figure of two dimensions. The area of any rectangle or square is the product of two adjacent sides, one of which may be called the base and the other the altitude. In general, any line segment that partially…

The arenaceous rocks (arenites) include all those clastic sedimentary rocks whose particle sizes range from 2 to 0.06 mm, or if silt is included, to 0.004 mm. Some arenites are composed primarily of carbonate particles, in which case they are called…

Clastic sedimentary rocks containing silt- or clay-sized particles that are less than 0.0625 mm and/or clay minerals. The argillaceous rocks (lutites) include shales, argillites, siltstones, and mudstones. They are the most abundant sedimentary rock…

A branch of mathematics dealing with numbers, operations on numbers, and computation. Arithmetic is useful in solving many practical problems, such as buying, selling, budgets, sports statistics, and measurement. The usual numbers of arithmetic are…

A sesquiterpene lactone (C15H22O5), derived from the leaves of Artemisia annua (sweet wormwood or qinghao), which is known for its antimalarial activity. Artemisinin (C15H22O5; see illustration) is an important antimalarial agent. Around 2000 years…

The name given a group of degenerative diseases of arteries characterized by thickening and hardening of their walls. The group includes three types of lesions: (1) atherosclerosis involves the aorta and its major branches; (2) medial sclerosis…

Groundwater conditions formed by water-bearing rocks (aquifers) in which the water is confined above and below by impermeable beds. These systems are named after the province of Artois in France, where artesian wells were first observed.Because the…

A group of highly fibrous, naturally occurring minerals with separable, long and thin fibers. Asbestos fibers are strong and flexible enough to be spun and woven as well as resistant to heat and chemicals. Historically, asbestos was used for fire…

The largest of the world's continents. With its peninsular extension, commonly called the continent of Europe, it is the major portion of the broad east-west extent of the Northern Hemisphere landmasses. In many ways Asia is more a cultural concept…

A layer of variable thickness within the upper mantle of the Earth that is mechanically weaker (less rigid) than both the overlying lithosphere and the underlying mesosphere. The depth of transition from lithosphere to asthenosphere can be as little…

An allergic inflammatory disease of the pulmonary airways, marked by labored breathing, wheezing, and coughing. Asthma is a serious pulmonary disease that inflames and narrows the airways of the lungs (Fig. 1). The inflammation involves mast cells,…

An abundant type of glial cell of the central nervous system. Astrocytes (Fig. 1) are specialized glial cells (nonneuronal cells that surround neurons) of the central nervous system (CNS) that exert numerous essential functions in both health and…

If the graph of a function y = f (x) goes out to infinity, each “end” of the graph may get closer and closer to a straight line, which is then called an asymptote. In other words, some straight line may well approximate the graph as the function…

The deposition of lipid with proliferation of fibrous connective tissue cells in the inner walls of the arteries. Atherosclerosis (Fig. 1) is the most common form of arteriosclerosis, which comprises a group of degenerative diseases of arteries…

The large body of seawater separating the continents of North and South America in the west from Europe and Africa in the east and extending south from the Arctic Ocean to the continent of Antarctica. The Atlantic is the second-largest ocean water…

A gaseous layer that envelops the Earth and most other planets in the solar system. Earth, Venus, Mars, Jupiter, Saturn, Uranus, Neptune, and Titan (Saturn's largest satellite) are all known to possess substantial atmospheres that are held by the…

A scientific discipline concerned with the chemical composition of the Earth's atmosphere. Topics falling within the field include the emission, transport, and deposition of atmospheric chemical species; the rates and mechanisms of chemical…

An annular coral reef, with or without small islets, that surrounds a lagoon without projecting land area. Physiography Most atolls are isolated reefs that rise from the deep sea. They vary considerably in size and shape. Small rings, some without…

The quantitative assessment of individual hearing, both normal and defective. In typical tests, pure tones are presented through headphones, though some tests use speech instead of tones. In bone conduction tests, tones are presented through a…

A group of monoclinic calcic pyroxenes which have the general chemical formula (Ca,Mg,Fe)(Mg,Fe)-Si2O6, in which calcium is the dominant cation in the first cation position. Monoclinic pyroxene with substantial iron or magnesium in place of calcium…

An optical manifestation of a large-scale electrical discharge process which surrounds the Earth. The discharge is powered by the so-called solar wind–magnetosphere generator. The Sun continuously blows out its upper atmosphere, the corona, with a…

An island continent situated in the Southern Hemisphere and extending from 10 to 44°S and from 113 to 153°E. Australia's total area (2,941,526 mi2 or 7,618,517 km2 for the Australian mainland and 26,383 mi2 or 68,332 km2 for the island of Tasmania)…

Minerals that are formed in sediment or a sedimentary rock. Their in-place origin distinguishes them from minerals that are formed elsewhere and transported to the site of deposition (detrital minerals). Authigenic minerals form at the Earth's…

In general, a large mass of snow, ice, rock, earth, or mud in rapid motion down a slope or over a precipice. In the English language, the term avalanche is reserved almost exclusively for snow avalanche. Minimal requirements for the occurrence of an…

An infectious viral disease primarily affecting fowl, with rare occurrences in humans. Avian influenza, also termed bird flu, is a viral disease caused by influenza A subtypes that primarily affect chickens, turkeys, migratory waterfowl, and other…