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An early mechanical calculator. The abacus likely originated in Babylonia sometime before 1000 BCE. Over the subsequent centuries, it became a commonplace device in many regions of the world. The abacus is still occasionally used as a cognitive…

A discipline that deals generally with the extraction of information from acoustic signals in the presence of noise and uncertainty. Acoustic signal processing has expanded from the improvement of music and speech sounds and a tool to search for oil…

There is a growing body of evidence that many of the thousands of prescription and over-the-counter medications ultimately make their way into water bodies and drinking-water supplies. Typical wastewater treatment plants may not be effective at…

A group of software development methods in which requirements and solutions evolve through collaboration between the developers and the customers. Agile methods have significantly changed the practice of software development since their inception…

A disease of the nervous system characterized by a progressive dementia that leads to profound impairment in cognition and behavior. Dementia occurs in a number of brain diseases where the impairment in cognitive abilities represents a decline from…

Any of a group of drugs of diverse chemical structure and physiological effects that are used for the relief of pain. Analgesics are drugs, including opiates, synthetic opioids, and salicylates, that are used primarily for pain relief (see…

A chemical substance, produced by microorganisms, plants, marine organisms, and synthetically, that has the capacity in dilute solutions to inhibit the growth of bacteria or destroy bacteria. Antibiotics are important antibacterial agents. Most are…

The capability that a bacterium acquires to counteract an inhibitory chemical molecule or compound that was formerly effective in killing it or preventing its growth. Antibiotic resistance in bacteria (Fig. 1) is a hot topic in the media and in…

Chemical compounds biosynthetically or synthetically produced that destroy or usefully suppress the growth or metabolism of a variety of microscopic or submicroscopic forms of life. On the basis of their primary activity, antimicrobial agents (see…

A group of diseases affecting joints or their component tissues. Arthritis is the collective term used to describe any joint disorder or process; it also typically involves inflammation. In common usage, arthritis often refers to any joint pain.…

Any treatment or procedure that includes the in-vitro handling of oocytes (immature ova or egg cells) and sperm or embryos for the purpose of establishing a pregnancy. Assisted reproductive technology (ART) is undertaken as a treatment of…

The most common type of arrhythmia (any disorder of the heart rate or rhythm). Atrial fibrillation, often abbreviated AFib or AF, is a heart condition that can lead to potentially serious complications. It is associated with decreased quality of…