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from article Bioorganic chemistry

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Intramolecular models of enzymatic general acid and general base catalysis. (a) Intramolecular general acid catalysis causes this acetal to hydrolyze at pH 7 more than 107 times faster than the corresponding acetal without the carboxylic acid group.…

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from article Bioorganic chemistry

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An antibody raised against the phosphonate analog of a tetrahedral intermediate catalyzes the hydrolysis of cocaine to ecgonine methyl ester.

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from article Bioorganic chemistry

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A functionalized cyclodextrin mimics the enzyme RNase by catalyzing the regioselective hydrolysis of a model phosphodiester.

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from article Bioorganic chemistry

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Enzyme-catalyzed reactions that have been commercialized as industrial processes.

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from article Bioorganic chemistry

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Mechanism of DNA scission by calicheamicin. Reductive or nucleophilic cleavage of the trisulfide triggers conjugate (Michael) addition to the enone, rehybridization of the bridgehead carbon, and Bergman cyclization of the enediyne, generating a…

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from article Type 1 diabetes

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One characteristic feature of type 1 diabetes is glomerulosclerosis (Kimmelstiel-Wilson lesion), which involves the scarring or hardening of the glomeruli (blood vessels) in the kidneys. (Copyright © McGraw-Hill Education)

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from article Type 1 diabetes

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Stages in the development of type 1 diabetes. (Credit: Type 1 Diabetes TrialNet)

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from article Parathyroid gland

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Common positions of human parathyroid glands on the posterior aspect of the thyroid. (After W. H. Hollinshead, Anatomy of the endocrine glands, Surg. Clin. N. Amer., 32(4):1115–1140, 1952)

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from article Parathyroid gland

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Section of human parathyroid gland, demonstrating the two main parenchymal cell types. Zenker-formal fixation, Mallory-azan stain. (After D. Bloom and D. W. Fawcett, A Textbook of Histology, 9th ed., Saunders, 1968)

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