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In humans and other mammals, DNA methylation involves the addition of a methyl group to a cytosine ring, forming methylcytosine. The methylation is carried out by a DNA methyltransferase (DNMT). (Copyright © McGraw-Hill Education)

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from article DNA methylation

Transcriptional silencing via DNA methylation. The methylated configuration blocks proteins that activate gene transcription, preventing them from acting as gene activators. (Copyright © McGraw-Hill Education)

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from article Microtechnique

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from article Microtechnique

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from article Microtechnique

Materials and method for applying cover slip to balsam wholemount. (a) Correct way; notice that the cover slip is held vertically centered over the drop of balsam. (b) Wrong way; this method draws the object to one side. (After P. Gray, Handbook of…

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from article Microtechnique

Making a smear preparation. (a) Place the drop about 1 in. (2.5 cm) from end of slide. (b) Apply a second slide just in front of the drop. (c) Push slide smoothly forward to spread the smear. (After P. Gray, Handbook of Basic Microtechnique, 3d ed.,…

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from article Microtechnique

Rotary microtome produced by the American Optical Co. (From P. Gray, Handbook of Basic Microtechnique, 3d ed., McGraw-Hill, 1964)

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from article Microtechnique

Method of mounting the wax block on the block holder. (After P. Gray, Handbook of Basic Microtechnique, 3d ed., McGraw-Hill, 1964)

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from article Microtechnique

Basic steps in cutting and mounting paraffin ribbons prior to staining. (a) Starting the ribbon. (b) Cutting the ribbon in lengths. (c) Mounting the dry ribbon. (d) Flooding the ribbons. (e) Warming the flooded ribbons to flatten them. (After P.…

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from article Microtechnique