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A common medicine used to relieve mild to moderate pain and reduce fever. Acetaminophen (N-acetyl-p-aminophenol), or paracetamol, is a white crystalline compound with the molecular formula C8H9NO2 (Fig. 1). It is a member of the aniline family of…

A disease of the nervous system characterized by a progressive dementia that leads to profound impairment in cognition and behavior. Dementia occurs in a number of brain diseases where the impairment in cognitive abilities represents a decline from…

The ongoing lower level of species extinction intensity occurring between episodes of mass extinctions. Extinction is a normal part of the history of life. Out of every 100 species that have ever lived on Earth, 99 are no longer in existence.…

A kind of mathematics whose variables can only be True or False. A variable is called Boolean if it can only hold two possible values: True or False. The value True can be represented by the number one and False by zero. For example, if A is a…

Any of the cells within a tumor that possess the capacity to self-renew and cause the heterogeneous lineages of cancerous cells that comprise the tumor. Cancer stem cells (CSCs) typically represent a small percentage of all cells in a tumor (rarely…

Any clouding or opacity of the crystalline lens of the eye. Loss of the transparency of the lens (see illustration) prevents the normal passage of light onto the light-sensitive retina at the back of the eye and thus a loss of visual ability.…

The administration of chemical substances for the treatment of disease, especially cancer, or for the prevention of aberrant growth of cells or tissues (neoplasms). In general, chemotherapy is the use of chemicals to treat any disease, but the term…

A genome-engineering technique that allows precise targeting of specific stretches of genetic code and editing of DNA at designated locations. The CRISPR/Cas9 system has been used as a general tool to engineer the genomes of many different…

A syndrome characterized by a generalized decline in cognition that is severe enough to cause functional impairment in daily activities. Dementia is a term used to describe a collection of symptoms of severe cognitive decline. Individuals suffering…

The interaction of the behavior and ecology of hosts with the biology of pathogens as relating to the impact of diseases on populations. Although human diseases have been studied from an ecological perspective for centuries, diseases in plant and…

A condition characterized by the paroxysmal recurrence of transient, uncontrollable episodes of abnormal neurological or mental function (or both). "Epilepsy" generally refers to the medical condition of recurrent, unprovoked seizures, and the term…

A mathematical system that details the properties and relationships of spatial objects such as points, lines, shapes, and planes. Euclidean geometry is also known as flat geometry or planar geometry, because planes in Euclidean geometry have the…

Typically, an aquatic vertebrate with scales, gills, and paired fins. Fishes (Fig. 1) are found throughout the world's waterways, from saltwater oceans to freshwater streams and ponds. About 35,000 species of fishes have been described to date. Many…

A biological organism whose genetic material has been manipulated artificially through genetic or genomic editing techniques. In contrast to the long history of artificial selection (domestication), in which humans selectively breed organisms to…

A space-traversing unmanned vehicle which contains the means for controlling its flight path and that delivers an explosive warhead with high accuracy. Various kinds of missiles are guided in the sense that they can aerodynamically adjust after…

Pathologies or aberrations in structure or function of blood cells or the blood-clotting mechanism. Hematologic disorders affect the blood and blood-forming organs. Although many diseases and abnormal conditions may be reflected by the blood and its…

The process of tissue death (necrosis) resulting from a failure of blood supply and lack of oxygen (anoxia) reaching the tissue's cells. The usual cause of infarction is occlusion (blockage or closing) of an artery by a thrombus (blood clot; see…

The entrance, growth, and multiplication of a microorganism or pathogen in the body of a host. Infection may or may not result in the establishment of a disease process, depending on many variables including the pathogen involved, the health of the…

The inverse function of an exponential function in mathematics. Stated less technically, a logarithm is the opposite of an exponent. Logarithms are used to solve equations in which the variable is an exponent. Historically, tables of logarithms…

A disease caused by members of the protozoan genus Plasmodium (a widespread group of protists that parasitize the human liver and red blood cells) and transmitted by the bite of the female Anopheles mosquito. Malaria is a serious mosquito-borne…

Impaired health caused by a dietary deficiency, excess, or imbalance. To support human life, energy (from fat, carbohydrate, and protein), water, and more than 40 different food substances must be obtained from the diet in appropriate amounts.…

A procedure used to remove toxins, fluids, and other substances from the body when the kidneys are unable to handle this removal naturally. In the medical field, medical dialysis is simply referred to as dialysis. The removal of toxins, fluids, and…

An autoimmune disease resulting from an abnormality in neuromuscular transmission, characterized by a fluctuating degree of muscle weakness. Myasthenia gravis is a chronic autoimmune neuromuscular disorder (see illustration) characterized by varying…

A progressive degenerative disorder of the nervous system belonging to a group of conditions called motor system disorders. Parkinson's disease—more specifically known as idiopathic Parkinson's disease to distinguish it from the four Parkinson-plus…

A branch of mathematics involving numerical measures of how likely it is that a particular event will occur. A probability is a number between 0 and 1. An event that will never occur has a probability of zero, and an event that is certain to occur…

In medicine and health sciences, a value expected for an individual whose state of health is known and well described, and the interval of values broadly expected for a population, respectively. Results of clinical laboratory tests and other…

A neurological condition in which there are recurrent seizures. Seizure disorders result from periodic disturbances to the electrical (nerve cell) activity of the brain, leading to temporary and uncontrolled brain dysfunction. Seizure conditions are…

A clinical condition caused by widespread impairment of blood flow resulting in an inadequate supply of oxygen to the body's tissues and organs. Shock is a response to hypoperfusion, which is the inadequate circulation of blood throughout the body.…

The field of knowledge concerned with collecting, analyzing, and presenting data. Statistical methods are regularly used by researchers in the physical, biological, and social sciences, as well as engineers, business managers, government officials…

A subdiscipline of paleobiology that investigates the processes of preservation and their influence on information in the fossil record. Taphonomy is the study of fossilization and considers the processes at work in the incorporation of living…

A rare genetic disorder in which there is a deficiency of hexosaminidase A (a lysosomal enzyme that hydrolyzes GM2 gangliosides). Tay-Sachs disease is a severe and progressive neurodegenerative disease. Because of the deficiency of hexosaminidase A…

The process of forming a thrombus, which is a solid mass or plug in the living heart or vessels composed of the constituents of the blood. Thrombosis usually occurs in a diseased blood vessel, as a result of arteriosclerosis. The consequences of…

An aqueous solution of organic and inorganic substances—mostly waste products of metabolism—that collects in the kidneys and is removed from the body primarily through the urinary bladder and urinary tract. Urine is a liquid waste produced by the…

Diseases that are transmitted from animals to humans. Zoonoses (the singular form is zoonosis) are also termed zoonotic diseases. They are infectious diseases passed from animals (Fig. 1) to humans. Zoonotic agents are found among all major…

The study of systems consisting of arbitrary sets of elements of unspecified type, together with certain operations satisfying prescribed lists of axioms. Abstract algebra has been developed since the mid-1920s and has become a basic idiom of…

A viral disease of humans caused by the human immunodeficiency virus (HIV), which attacks and compromises the body's immune system. Individuals infected with the human immunodeficiency virus (HIV) proceed through a spectrum of stages that ultimately…

Habituation to a specific practice, such as drinking alcoholic beverages or using drugs (for example, heroin, cocaine, or amphetamines), and disorders characterized by the chronic use of a drug, alcohol, or similar substance. Addiction and addictive…

Malfunctions of the paired adrenal glands. The paired adrenal glands are complex endocrine organs in proximity to the kidneys (see illustration), and disorders of the adrenal glands can have serious consequences. Under specific circumstances,…

Mechanized systems of food and fiber production used in agriculture. The mechanized systems comprising agricultural machinery are utilized in numerous aspects of agriculture, including the initial tillage of the soil (Fig. 1), planting, cultural…

The repeated and/or excessive use of alcohol (ethanol) that continues despite negative physical, psychiatric, or social consequences. Alcoholism is characterized by consuming alcohol more often, in larger amounts, or over longer periods than…

A small, tropical, evergreen tree (Pimenta dioica) and its dried, unripe fruit (berry). Allspice (Pimenta dioica; alternatively, P. officinalis) [see illustration] is a member of the myrtle family (Myrtaceae). Allspice, which is also known as…

Most commonly, a generic name for all fossil resins, although it has been restricted by some to refer only to succinite, the mineralogical species of fossil resin that includes most of the Baltic Coast deposits. The time necessary to transform resin…

Any of the organic compounds possessing one or more basic amino groups and one or more acidic carboxyl groups. Of the more than 80 amino acids that have been found in living organisms, approximately 20 serve as the building blocks for proteins.…

A statistical technique that partitions the total variation in experimental data into components assignable to specific sources. Analysis of variance is applicable to data for which (1) effects of sources are additive, (2) uncontrolled or…

A class of steroid hormones produced in the testes and adrenal cortex that act to regulate masculine secondary sexual characteristics. The major naturally occurring androgens, such as testosterone, are C-19 steroids (that is, they each contain 19…

A synthetic manufactured drug derived from the male sex hormone testosterone. Androgenic-anabolic steroids, often termed simply as anabolic steroids, are artificially produced testosterone variants. They can provide a number of medical benefits when…

Loss of sensation with or without loss of consciousness. Anesthesia is used to prevent pain during surgery and other medical procedures. There are several ways of producing anesthesia, with the choice dependent on the type of surgery and the medical…

The use of live nonhuman animals for scientific research and experimentation. Animal testing has been a cornerstone of biomedical research, having contributed greatly to the understanding of human biology, to the unraveling of the complex underlying…

A type of drug that inhibits the combination of histamine with histamine receptors. Antihistamine drugs are termed either H-1 or H-2 receptor antagonists, depending on which type of histamine receptor is involved. H-1 receptor antagonists are used…

A genus of fossil birds in the extinct order Archaeopterygiformes, characterized by flight feathers like those of modern birds. Archaeopteryx is generally accepted as the oldest known fossil bird. It represents a unique snapshot of evolution; most…

Any vegetable that is prevalent in Asian cuisines, but less well known in Western diets. Asian vegetables (Fig. 1), also referred to as Asian greens or oriental vegetables, are very important in Asian countries, but are not as popular in North…

Any treatment or procedure that includes the in-vitro handling of oocytes (immature ova or egg cells) and sperm or embryos for the purpose of establishing a pregnancy. Assisted reproductive technology (ART) is undertaken as a treatment of…

A highly contagious intestinal disease, also known as shigellosis, caused by rod-shaped bacteria of the genus Shigella. Bacillary dysentery, which also is referred to as shigellosis, is a significant intestinal infection. Rod-shaped bacteria of the…

Any of a group of drugs used for the suppression of anxiety, the induction of sleep, and the control of seizures. Barbiturates are sedative-hypnotic drugs, derived from barbituric acid, that act as central nervous system depressants (see…

The drug as well as the plant known as deadly nightshade (Atropa belladonna). The belladonna plant (Atropa belladonna; see illustration) belongs to the nightshade family, Solanaceae, in the order Solanales. The plant is a coarse and poisonous…

A discipline that combines biology, mathematics, and computer science to acquire, store, analyze, and disseminate complex biological data. The term bioinformatics was coined by Paulien Hogeweg and Ben Hesper in the early 1970s to describe the "the…

A biological product used to induce immunity to various infectious diseases or noxious substances of biological origin. Biological products, or simply biologicals, are usually limited to immune serums, antitoxins, vaccines (see illustration), and…

Identifying exposure sources, routes, frequency, duration, and magnitude using biomarker data combined with other approaches, such as computational models and available environmental measurement data. The goal of environmental health science is to…

The application of chemical engineering principles to the solution of medical problems due to physiological impairment. Knowledge of organic chemistry is required of all chemical engineers, and many study biochemistry and molecular biology. This…

An integrated device consisting of a biological recognition element and a transducer capable of detecting the biological reaction and converting it into a signal that can be processed. Ideally, the sensor should be self-contained, so that it is not…

Malignant and benign lesions of the human mammary glands. Breast cancer and other breast disorders are potentially serious medical conditions. Benign breast disorders are often symptomatic and bothersome, but do not have malignant potential.…

A rare inflammatory lung disease affecting the small airways (bronchioles) and air sacs (alveoli) of the respiratory system. Bronchiolitis obliterans organizing pneumonia (BOOP) was first described in 1985 by Gary Epler as a disease distinct from…

An infectious disease of various animals and humans caused by Brucella bacteria. Brucellosis (also known as Malta fever, Mediterranean fever, and undulant fever) is a significant disease of many animals. It affects numerous mammals, primarily…

In its simplest form, a vector is a directed line segment. Physical quantities, such as velocity, acceleration, force, and displacement, are vector quantities, or simply vectors, because they can be represented by directed line segments. The algebra…

The common name for a malignant neoplasm or tumor. Cancer is a serious medical condition that develops when the orderly relationship of cell division and cell differentiation becomes disordered, leading to the development of neoplasms. Neoplasms are…

A genus comprising yeasts that cause a variety of human diseases referred to as candidiasis. All Candida species are single-celled yeasts (fungal organisms) that are ovoid in shape and 3–5 μm in size, and they multiply by a process called budding.…

Any of the group of organic compounds consisting of carbon, hydrogen, and oxygen that includes sugars, starches, and cellulose. Carbohydrate compounds consist of carbon, hydrogen, and oxygen, with the general chemical formula Cm(H2O)n [Fig. 1]; the…

A condition caused by the thickening of ligaments and tendon sheaths at the wrist, with consequent compression of the median nerve at the palm. The carpal tunnel is a thin passageway among ligaments and tendon sheaths located in the wrist joint area…

A medium-sized, spreading evergreen tree (Anacardium occidentale), which is grown widely in the tropics for its kidney-shaped edible nuts (also called cashews) and the resinous oil in the shells of the nuts. Cashew trees, which are native to Brazil,…

A class in the phylum Mollusca that is exclusively marine and includes squids, octopuses, and cuttlefishes. The molluscan class Cephalopoda is one of the major taxonomic groupings of marine animals and contains both extant members—squids (Fig. 1),…

Any member of the grass family (Poaceae or Gramineae) that produces edible grains usable as food by humans and livestock. Cereals are important cultivated crops. Common cereals include rice, wheat, barley, oats, maize (corn), sorghum, rye, and…

An order of the class Reptilia, including the turtles, terrapins, and tortoises; also termed Testudines. The order Chelonia (often referred to as Testudines) comprises one of the oldest groups of reptiles on Earth. Members of the Chelonia…

A re-emerging arthropod-borne viral (arboviral) disease that is most often characterized by the sudden onset of high fever and severe joint pain (arthralgia), which can persist for years following acute illness. Chikungunya viruses are usually…

An illness of unknown cause and uncertain prevalence, often resulting in debilitating fatigue accompanied by diverse symptoms. Chronic fatigue syndrome (CFS) is a complicated and disabling illness. Characterized by extreme degrees of fatigue (see…

A lung condition that is characterized by limitation of airflow from the lungs and manifests with shortness of breath, cough, and sputum production. Chronic obstructive pulmonary disease (COPD) is a significant cause of disease and death. COPD is…

An evergreen shrub or small tree, particularly Cinnamomum verum, and the spice obtained from the plant's bark. The cinnamon plant (see illustration) is a member of the laurel family (Lauraceae) in the order Laurales. Native to Sri Lanka, the…

Pathologies and abnormal conditions that involve the circulatory system. Circulation disorders include both localized disturbances of circulation and diseases of the circulatory system (Fig. 1). Circulation 1 Illustration of the thickening and…

A branch of clinical pathology concerned with the role of the immune defense system in disease. The subject of clinical immunology encompasses diseases where a malfunction of the immune system itself is the basic cause, together with diseases where…

The adaptation of microbiological techniques to the study of the etiological agents of infectious disease. Clinical microbiology, also termed medical microbiology, is a branch of science concerned with the investigation of pathogenic microorganisms…

A Gram-positive, anaerobic, spore-forming bacterium that causes a severe form of antibiotic-associated diarrhea. Clostridioides difficile (formerly Clostridium difficile and often abbreviated as C. diff) [Fig. 1] is a rod-shaped bacterium…

An infectious viral disease of the upper respiratory system characterized by inflammation of the mucus membranes of the nose, throat, eyes, and eustachian tubes, leading to watery mucus production that turns purulent (containing pus). Common colds…

A natural and extremely useful extension of the familiar real numbers. They can be introduced formally as follows. Consider the two-dimensional real vector space consisting of all ordered pairs (a1, a2) of real numbers. Geometrically this space can…

Structural or functional abnormalities of the body that develop during embryogenesis and the fetal period; also called birth defects. Congenital anomalies, or birth defects, are conditions present at or from birth that deviate from the body's normal…

Any living or fossil member of the plant division Pinophyta, consisting chiefly of woody trees or shrubs that produce cones and evergreen needles. Conifers are predominantly cone-bearing, evergreen trees and shrubs belonging to the order Pinales, as…

Any of a group of diseases involving connective tissue as the pathological target. Connective tissue comprises one of the primary tissues of the body and is distinguished by an abundance of fibrillar and nonfibrillar extracellular components, which…

Any of a group of viruses that cause upper and lower respiratory tract diseases, gastroenteritis, hepatitis, and central nervous system infections in birds and mammals, including humans. Coronaviruses (Fig. 1) comprise a major group of common animal…

A laboratory test performed prior to a blood transfusion to determine whether donor blood is compatible with the recipient's blood. Choosing a blood donor who is compatible with the recipient is vital. Therefore, crossmatching between the donor and…

A curve traced in the plane by a point on a circle that rolls, without slipping, on a line. If the line is the x axis of a rectangular coordinate system, at whose origin O the moving point P touches the axis, parametric equations of the cycloid are…

The use of data analytics and informatics-based approaches to discriminate between potential environmental contaminants and noncontaminants. New and emerging environmental contaminants are chemicals that have not been previously detected or that are…

A medical disorder in humans that results from a sudden reduction in atmospheric pressure. Decompression illness—also called decompression sickness, dysbarism, caisson disease, the bends, and compressed-air illness—is a physiological condition…

Disorders characterized by the gradual and progressive loss of nerve cells. Degenerative neural diseases, or neurodegenerative diseases (see illustration), are pathological conditions that result in the progressive degeneration or death of neurons…

A mosquito-borne viral infection throughout the world's tropical and subtropical zones. Dengue fever (also known as breakbone fever and dandy fever) is an acute viral disease of humans characterized by fever, rash, prostration, and lymphadenopathy.…

Inflammation of the skin; also known as eczema. Dermatitis, or eczema, is a general medical term that describes irritation or inflammation of the skin. Typically, the inflammation of the skin involves redness and scaling (see illustration). In acute…

Any of various abnormal metabolic conditions characterized by excessive levels of sugar glucose in the blood and tissues of the body, as well as excessive urinary output, thirst, and hunger; in common usage, usually refers to diabetes mellitus.…

The passage of loose or watery stools, usually at more frequent than normal intervals. Diarrhea is characterized by more-frequent and abnormally loose or watery stools (greater than 227 g or 8 oz per 24 h). The two principal mechanisms responsible…

A branch of mathematics that deals with intrinsic properties of curves and surfaces in three-dimensional Euclidean space. The intrinsic properties are those which are independent of the geometrical object's orientation or location in space. The…

An acute infectious disease of humans caused by Corynebacterium diphtheriae. Diphtheria is a contagious and potentially life-threatening infectious disease. The causative agent is the bacterium Corynebacterium diphtheriae (see illustration).…

A deleterious set of responses occurring at the subcellular level, stimulated by infection, injury, or genetic or developmental errors, and manifested in altered structure or functioning of the affected organism. Disease is considered to be a…

In arithmetic and algebra, the process of finding one of two factors of a number (or polynomial) when their product and one of the factors are given. The symbol ÷ now used mostly in elementary English and American arithmetics to denote division…

A system that delivers controlled amounts of a therapeutic agent over a prolonged period or in a desirable temporal fashion, thereby maintaining required plasma or tissue drug levels. Drug delivery systems are bioengineered mechanisms or devices…