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The apparent change in direction of a celestial source of light caused by an observer's component of motion perpendicular to the impinging rays. In astronomy, aberration manifests, for example, as a star appearing aberrantly from what its true…

A common medicine used to relieve mild to moderate pain and reduce fever. Acetaminophen (N-acetyl-p-aminophenol), or paracetamol, is a white crystalline compound with the molecular formula C8H9NO2 (Fig. 1). It is a member of the aniline family of…

Technologies to optimize the performance of optical systems wherein controllable optical elements maintain a sharply focused image in the presence of wavefront aberrations. The practical development of adaptive optics started in the late 1960s. Main…

A disease of the nervous system characterized by a progressive dementia that leads to profound impairment in cognition and behavior. Dementia occurs in a number of brain diseases where the impairment in cognitive abilities represents a decline from…

A member of a group of organic compounds that can be considered as derived from ammonia by replacement of one or more hydrogens by organic functional groups. Generally amines are bases of widely varying strengths, but a few that are acidic are…

An analytical technique for determining the composition of a sample in terms of the chemical elements present and their quantities or concentrations. Unlike other methods of elemental analysis, however, the sample is decomposed into its constituent…

A kind of mathematics whose variables can only be True or False. A variable is called Boolean if it can only hold two possible values: True or False. The value True can be represented by the number one and False by zero. For example, if A is a…

Any of the cells within a tumor that possess the capacity to self-renew and cause the heterogeneous lineages of cancerous cells that comprise the tumor. Cancer stem cells (CSCs) typically represent a small percentage of all cells in a tumor (rarely…

Light emitted by a high-speed charged particle when the particle passes through a transparent, nonconducting, solid material at a speed greater than the speed of light in the material. The emission of Cerenkov radiation—also spelled Cherenkov—is…

The attractive force that holds atoms or ions together. Chemical bonds are very strong. To break one bond in each molecule in a mole of material typically requires an energy of many tens of kilocalories.It is convenient to classify chemical bonding…

The administration of chemical substances for the treatment of disease, especially cancer, or for the prevention of aberrant growth of cells or tissues (neoplasms). In general, chemotherapy is the use of chemicals to treat any disease, but the term…

A chemical element, Cl, atomic number 17 and atomic weight 35.453. Chlorine exists as a greenish-yellow gas at ordinary temperatures and pressures (see illustration). It is second in reactivity only to fluorine among the halogen elements, and hence…

A genome-engineering technique that allows precise targeting of specific stretches of genetic code and editing of DNA at designated locations. The CRISPR/Cas9 system has been used as a general tool to engineer the genomes of many different…

The interaction of the behavior and ecology of hosts with the biology of pathogens as relating to the impact of diseases on populations. Although human diseases have been studied from an ecological perspective for centuries, diseases in plant and…

The adaptation of an animal or plant through breeding in captivity to a life intimately associated with and advantageous to humans. Domesticated plants and animals differ genetically and morphologically from their wild counterparts, often in ways…

The spinning of the Earth upon its planetary axis and movement of the Earth around the Sun. While appearing constant, the Earth's rate of rotation, where one complete rotation is measured as a day, and the rate of the Earth orbital motion around the…

One of the two places in the sky where the ecliptic crosses the celestial equator, or one of the two times of the year when the Sun crosses these points. The ecliptic is the great circle across the sky that marks the mean path of the Sun; the…

A mathematical system that details the properties and relationships of spatial objects such as points, lines, shapes, and planes. Euclidean geometry is also known as flat geometry or planar geometry, because planes in Euclidean geometry have the…

Planets beyond our solar system. For millennia, humankind has known about most of the major planets in our solar system because these worlds are visible to the naked eye. Exoplanets, however, were not indisputably known until 1995, when astronomers…

In thermodynamics, the amount of useful work that can be extracted from a closed thermodynamic system. The Helmholtz free energy applies to a process that takes place at a constant temperature T (isothermal process). The Gibbs free energy applies to…

A biological organism whose genetic material has been manipulated artificially through genetic or genomic editing techniques. In contrast to the long history of artificial selection (domestication), in which humans selectively breed organisms to…

Pathologies or aberrations in structure or function of blood cells or the blood-clotting mechanism. Hematologic disorders affect the blood and blood-forming organs. Although many diseases and abnormal conditions may be reflected by the blood and its…

A space telescope mission dedicated to detecting exoplanets. The tenth mission launched under the National Aeronautics and Space Administration's (NASA's) Discovery Program, Kepler was the agency’s first mission dedicated to the search for planets…

A salt or ester of lactic acid (CH3CHOHCOOH). In lactates, the acidic hydrogen of the carboxyl group has been replaced by a metal or an organic radical. Lactates are optically active, with a chiral center at carbon 2. The two optical isomers of a…

The inverse function of an exponential function in mathematics. Stated less technically, a logarithm is the opposite of an exponent. Logarithms are used to solve equations in which the variable is an exponent. Historically, tables of logarithms…

A disease caused by members of the protozoan genus Plasmodium (a widespread group of protists that parasitize the human liver and red blood cells) and transmitted by the bite of the female Anopheles mosquito. Malaria is a serious mosquito-borne…

The planet fourth outward from the Sun and the planet most like Earth in terms of geology, climate, and suitability for life. Mars is nicknamed the "Red Planet" for its reddish hue (Fig. 1). Besides Earth, Mars is the most-studied world in the solar…

An analytical technique for identification of chemical structures, determination of mixtures, and quantitative elemental analysis by measuring the mass-to-charge (m/z) ratio of ions produced when a sample is ionized. Determination of organic and…

A procedure used to remove toxins, fluids, and other substances from the body when the kidneys are unable to handle this removal naturally. In the medical field, medical dialysis is simply referred to as dialysis. The removal of toxins, fluids, and…

A device that is capable of converting chemical energy into electrical energy with the use of whole bacterial cells as the catalyst. Fuels that are produced biologically are known as biofuels. Biofuel cells convert chemical energy from organic…

An autoimmune disease resulting from an abnormality in neuromuscular transmission, characterized by a fluctuating degree of muscle weakness. Myasthenia gravis is a chronic autoimmune neuromuscular disorder (see illustration) characterized by varying…

A chemical element, Os, atomic number 76, atomic weight 190.2. Osmium is a hard white metal of rare natural occurrence, and is usually found in nature alloyed with other platinum metals. Metal Periodic table Platinum The periodic table of the…

A two-component reaction involving the loss of electrons (oxidation) by one chemical species and the gain of electrons (reduction) by another; also known as a redox reaction. Both oxidation and reduction occur simultaneously and in equivalent…

A progressive degenerative disorder of the nervous system belonging to a group of conditions called motor system disorders. Parkinson's disease—more specifically known as idiopathic Parkinson's disease to distinguish it from the four Parkinson-plus…

A slow change in the direction of the axis of rotation of the Earth as well as a very small change in the orientation of the Earth's orbit around the Sun. As a consequence of the precession of equinoxes, both the celestial equator (the projection of…

A branch of mathematics involving numerical measures of how likely it is that a particular event will occur. A probability is a number between 0 and 1. An event that will never occur has a probability of zero, and an event that is certain to occur…

The study of chemical changes resulting from the absorption of high-energy ionizing radiation. Such radiation includes alpha particles, electrons, gamma rays, fission fragments, protons, deuterons, helium nuclei, and heavier charged projectiles.…

In medicine and health sciences, a value expected for an individual whose state of health is known and well described, and the interval of values broadly expected for a population, respectively. Results of clinical laboratory tests and other…

The second largest planet in the solar system and the sixth in order of distance from the Sun. The outermost planet known prior to 1781 CE, Saturn is surrounded by a system of rings far more extensive than any other in the solar system (Fig. 1), as…

The field of knowledge concerned with collecting, analyzing, and presenting data. Statistical methods are regularly used by researchers in the physical, biological, and social sciences, as well as engineers, business managers, government officials…

A rare genetic disorder in which there is a deficiency of hexosaminidase A (a lysosomal enzyme that hydrolyzes GM2 gangliosides). Tay-Sachs disease is a severe and progressive neurodegenerative disease. Because of the deficiency of hexosaminidase A…

An instrument used to collect, measure, or analyze electromagnetic or other radiation from distant objects. A telescope overcomes the limitations of the human vision by increasing the ability to see faint objects and discern fine details. In…

The process of forming a thrombus, which is a solid mass or plug in the living heart or vessels composed of the constituents of the blood. Thrombosis usually occurs in a diseased blood vessel, as a result of arteriosclerosis. The consequences of…

One of the elements of atomic numbers 21–31, 39–49, and 71–81. The symbols of these elements, along with their atomic numbers and valence-shell electronic configurations, are given in Fig. 1. The elements are arranged in the order in which they…

An aqueous solution of organic and inorganic substances—mostly waste products of metabolism—that collects in the kidneys and is removed from the body primarily through the urinary bladder and urinary tract. Urine is a liquid waste produced by the…

A chemical obtained from wood. Woody plants comprise the greatest part of the organic materials produced by photosynthesis on a renewable basis. Replacement of fossil hydrocarbons, from which most organic chemicals are derived, is possible in many…

The scattering of x-rays by matter with accompanying variation in intensity for specific directions (or wavelengths) due to interference effects. X-ray diffraction is a powerful and readily available method for determining atomic arrangements in…

Diseases that are transmitted from animals to humans. Zoonoses (the singular form is zoonosis) are also termed zoonotic diseases. They are infectious diseases passed from animals (Fig. 1) to humans. Zoonotic agents are found among all major…

The study of systems consisting of arbitrary sets of elements of unspecified type, together with certain operations satisfying prescribed lists of axioms. Abstract algebra has been developed since the mid-1920s and has become a basic idiom of…

An increase in the expansion rate of the universe, attributed to dark energy. In 1998, astronomers presented evidence that the universe's expansion is not slowing down, as would be expected due to the gravity from the abundances of matter strewn…

A viral disease of humans caused by the human immunodeficiency virus (HIV), which attacks and compromises the body's immune system. Individuals infected with the human immunodeficiency virus (HIV) proceed through a spectrum of stages that ultimately…

Habituation to a specific practice, such as drinking alcoholic beverages or using drugs (for example, heroin, cocaine, or amphetamines), and disorders characterized by the chronic use of a drug, alcohol, or similar substance. Addiction and addictive…

Malfunctions of the paired adrenal glands. The paired adrenal glands are complex endocrine organs in proximity to the kidneys (see illustration), and disorders of the adrenal glands can have serious consequences. Under specific circumstances,…

The repeated and/or excessive use of alcohol (ethanol) that continues despite negative physical, psychiatric, or social consequences. Alcoholism is characterized by consuming alcohol more often, in larger amounts, or over longer periods than…

A useful carbon-carbon bond-forming reaction in which aldehyde and alcohol functional groups are observed during the reaction. The aldol reaction was first reported by Aleksandr Porfiryevich Borodin, who observed the reaction using pentanal and…

Any of the organic compounds possessing one or more basic amino groups and one or more acidic carboxyl groups. Of the more than 80 amino acids that have been found in living organisms, approximately 20 serve as the building blocks for proteins.…

A statistical technique that partitions the total variation in experimental data into components assignable to specific sources. Analysis of variance is applicable to data for which (1) effects of sources are additive, (2) uncontrolled or…

A class of steroid hormones produced in the testes and adrenal cortex that act to regulate masculine secondary sexual characteristics. The major naturally occurring androgens, such as testosterone, are C-19 steroids (that is, they each contain 19…

A synthetic manufactured drug derived from the male sex hormone testosterone. Androgenic-anabolic steroids, often termed simply as anabolic steroids, are artificially produced testosterone variants. They can provide a number of medical benefits when…

Loss of sensation with or without loss of consciousness. Anesthesia is used to prevent pain during surgery and other medical procedures. There are several ways of producing anesthesia, with the choice dependent on the type of surgery and the medical…

The use of live nonhuman animals for scientific research and experimentation. Animal testing has been a cornerstone of biomedical research, having contributed greatly to the understanding of human biology, to the unraveling of the complex underlying…

A type of drug that inhibits the combination of histamine with histamine receptors. Antihistamine drugs are termed either H-1 or H-2 receptor antagonists, depending on which type of histamine receptor is involved. H-1 receptor antagonists are used…

The application of chemical techniques to the study of archeological materials in order to elucidate aspects of the human past. The materials used in archeological chemistry might be anthropogenic (for example, pottery or metal) or natural (from…

Any treatment or procedure that includes the in-vitro handling of oocytes (immature ova or egg cells) and sperm or embryos for the purpose of establishing a pregnancy. Assisted reproductive technology (ART) is undertaken as a treatment of…

The study of the universe and the objects in it through scientific investigation. The goal of astronomical research is to understand celestial objects and the nature and evolution of the cosmos (Fig. 1). Because much of contemporary astronomy uses…

The study of the stars, galaxies, and other objects outside of the Solar System, with attention to physical causes. Astrophysics developed in the late 19th century, taking over from the mere mapping of positions of objects that had been the…

A chemical reaction or series of reactions leading to the predominant or exclusive formation of a single enantiomer, that is, one of an isomeric pair of chemical compounds whose molecules are nonsuperimposable mirror images. Enantiomers are said to…

A device that uses an internal resonance frequency of atoms (or molecules) to measure the passage of time. Atomic clocks (Fig. 1) are relied on internationally as the most accurate time and frequency standards with myriad uses in commerce, industry,…

A highly contagious intestinal disease, also known as shigellosis, caused by rod-shaped bacteria of the genus Shigella. Bacillary dysentery, which also is referred to as shigellosis, is a significant intestinal infection. Rod-shaped bacteria of the…

Any of a group of drugs used for the suppression of anxiety, the induction of sleep, and the control of seizures. Barbiturates are sedative-hypnotic drugs, derived from barbituric acid, that act as central nervous system depressants (see…

The drug as well as the plant known as deadly nightshade (Atropa belladonna). The belladonna plant (Atropa belladonna; see illustration) belongs to the nightshade family, Solanaceae, in the order Solanales. The plant is a coarse and poisonous…

An aromatic hydro­carbon, molecular formula C6H6, also know as benzol. Benzene is a clear, colorless, and flammable liquid which boils at 80.1°C and freezes at 5.5°C.Benzene (1) is an important chemical intermediate used to produce ethylbenzene…

The theory that the universe began in a hot, dense state and has since expanded and cooled. The big bang is the generally accepted cosmological theory for the origin, properties, and evolution of the universe (Fig. 1). Cosmology Universe 1 Timeline…

The study of skeletal remains from archeological sites by biological (or physical) anthropologists. Bioarcheology differs in several ways from traditional skeletal research (see illustration). Previous work focused on individual case studies (for…

A discipline that combines biology, mathematics, and computer science to acquire, store, analyze, and disseminate complex biological data. The term bioinformatics was coined by Paulien Hogeweg and Ben Hesper in the early 1970s to describe the "the…

A biological product used to induce immunity to various infectious diseases or noxious substances of biological origin. Biological products, or simply biologicals, are usually limited to immune serums, antitoxins, vaccines (see illustration), and…

Identifying exposure sources, routes, frequency, duration, and magnitude using biomarker data combined with other approaches, such as computational models and available environmental measurement data. The goal of environmental health science is to…

The application of chemical engineering principles to the solution of medical problems due to physiological impairment. Knowledge of organic chemistry is required of all chemical engineers, and many study biochemistry and molecular biology. This…

An integrated device consisting of a biological recognition element and a transducer capable of detecting the biological reaction and converting it into a signal that can be processed. Ideally, the sensor should be self-contained, so that it is not…

A region of spacetime exerting a gravitational field so strong that neither matter nor radiation can escape. Black holes are extreme cosmic objects predicted by German-born U.S. physicist Albert Einstein's theory of general relativity. Within a…

Malignant and benign lesions of the human mammary glands. Breast cancer and other breast disorders are potentially serious medical conditions. Benign breast disorders are often symptomatic and bothersome, but do not have malignant potential.…

A rare inflammatory lung disease affecting the small airways (bronchioles) and air sacs (alveoli) of the respiratory system. Bronchiolitis obliterans organizing pneumonia (BOOP) was first described in 1985 by Gary Epler as a disease distinct from…

An infectious disease of various animals and humans caused by Brucella bacteria. Brucellosis (also known as Malta fever, Mediterranean fever, and undulant fever) is a significant disease of many animals. It affects numerous mammals, primarily…

In its simplest form, a vector is a directed line segment. Physical quantities, such as velocity, acceleration, force, and displacement, are vector quantities, or simply vectors, because they can be represented by directed line segments. The algebra…

The measurement of the quantity of heat transferred during chemical reactions, changes of state, mixing of substances, as well as other chemical and physical processes. The unit of energy in the International System of Units is the joule, symbolized…

The common name for a malignant neoplasm or tumor. Cancer is a serious medical condition that develops when the orderly relationship of cell division and cell differentiation becomes disordered, leading to the development of neoplasms. Neoplasms are…

A genus comprising yeasts that cause a variety of human diseases referred to as candidiasis. All Candida species are single-celled yeasts (fungal organisms) that are ovoid in shape and 3–5 μm in size, and they multiply by a process called budding.…

Any of the group of organic compounds consisting of carbon, hydrogen, and oxygen that includes sugars, starches, and cellulose. Carbohydrate compounds consist of carbon, hydrogen, and oxygen, with the general chemical formula Cm(H2O)n [Fig. 1]; the…

A condition caused by the thickening of ligaments and tendon sheaths at the wrist, with consequent compression of the median nerve at the palm. The carpal tunnel is a thin passageway among ligaments and tendon sheaths located in the wrist joint area…

A branch of physical chemistry that seeks to explain time-dependent phenomena, such as energy transfer and chemical reaction, in terms of the detailed motion of the nuclei and electrons that constitute the system. As such, chemical dynamics seeks…

A re-emerging arthropod-borne viral (arboviral) disease that is most often characterized by the sudden onset of high fever and severe joint pain (arthralgia), which can persist for years following acute illness. Chikungunya viruses are usually…

A white or colorless amorphous polysaccharide that forms a base for the hard outer integuments of crustaceans, insects, and other invertebrates. Chitin (see illustration) is an important nitrogenous polysaccharide that is found abundantly in nature.…

An illness of unknown cause and uncertain prevalence, often resulting in debilitating fatigue accompanied by diverse symptoms. Chronic fatigue syndrome (CFS) is a complicated and disabling illness. Characterized by extreme degrees of fatigue (see…

A lung condition that is characterized by limitation of airflow from the lungs and manifests with shortness of breath, cough, and sputum production. Chronic obstructive pulmonary disease (COPD) is a significant cause of disease and death. COPD is…

Pathologies and abnormal conditions that involve the circulatory system. Circulation disorders include both localized disturbances of circulation and diseases of the circulatory system (Fig. 1). Circulation 1 Illustration of the thickening and…

A branch of clinical pathology concerned with the role of the immune defense system in disease. The subject of clinical immunology encompasses diseases where a malfunction of the immune system itself is the basic cause, together with diseases where…

The adaptation of microbiological techniques to the study of the etiological agents of infectious disease. Clinical microbiology, also termed medical microbiology, is a branch of science concerned with the investigation of pathogenic microorganisms…

A Gram-positive, anaerobic, spore-forming bacterium that causes a severe form of antibiotic-associated diarrhea. Clostridioides difficile (formerly Clostridium difficile and often abbreviated as C. diff) [Fig. 1] is a rod-shaped bacterium…

An infectious viral disease of the upper respiratory system characterized by inflammation of the mucus membranes of the nose, throat, eyes, and eustachian tubes, leading to watery mucus production that turns purulent (containing pus). Common colds…

A natural and extremely useful extension of the familiar real numbers. They can be introduced formally as follows. Consider the two-dimensional real vector space consisting of all ordered pairs (a1, a2) of real numbers. Geometrically this space can…