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A common medicine used to relieve mild to moderate pain and reduce fever. Acetaminophen (N-acetyl-p-aminophenol), or paracetamol, is a white crystalline compound with the molecular formula C8H9NO2 (Fig. 1). It is a member of the aniline family of…

Technologies to optimize the performance of optical systems wherein controllable optical elements maintain a sharply focused image in the presence of wavefront aberrations. The practical development of adaptive optics started in the late 1960s. Main…

A disease of the nervous system characterized by a progressive dementia that leads to profound impairment in cognition and behavior. Dementia occurs in a number of brain diseases where the impairment in cognitive abilities represents a decline from…

A member of a group of organic compounds that can be considered as derived from ammonia by replacement of one or more hydrogens by organic functional groups. Generally amines are bases of widely varying strengths, but a few that are acidic are…

A conductor whose purpose is to emit and/or receive electromagnetic waves using the bulk oscillations of electric charges within the conductor. The conduction electrons in antennas are free to move throughout the conductor. The electrons form a bulk…

The subfield of computer science concerned with understanding the nature of intelligence and constructing computer systems capable of intelligent behavior. Many activities, such as perception, learning, planning, natural language, and understanding,…

Earth's oldest desert and the most arid place outside of Antarctica's Dry Valleys. Located along the edge of the Pacific Ocean and to the west of the Andes in Chile's Antofagasta Province, the Atacama Desert (Fig. 1) has long been recognized as…

An analytical technique for determining the composition of a sample in terms of the chemical elements present and their quantities or concentrations. Unlike other methods of elemental analysis, however, the sample is decomposed into its constituent…

A quantum-mechanical theory of the motion of electrons in solids. The band theory of solids' name comes from the fact that it predicts certain restricted ranges, or bands, for the energies of electrons in solids. In a solid, the energy level of an…

Any of the cells within a tumor that possess the capacity to self-renew and cause the heterogeneous lineages of cancerous cells that comprise the tumor. Cancer stem cells (CSCs) typically represent a small percentage of all cells in a tumor (rarely…

Cameras in mobile phones or smartphones that can capture images and videos.The cellphone, the world’s favorite must-have gadget, has been with us for nearly a half-century, while experiencing continuous and often phenomenal improvements. Much of the…

An apparent outward force on a particle rotating about an axis which, by Newton's third law, is equal and opposite to the centripetal force. In classical mechanics, a particle that is rotating about an axis experiences an apparent outward…

Light emitted by a high-speed charged particle when the particle passes through a transparent, nonconducting, solid material at a speed greater than the speed of light in the material. The emission of Cerenkov radiation—also spelled Cherenkov—is…

The attractive force that holds atoms or ions together. Chemical bonds are very strong. To break one bond in each molecule in a mole of material typically requires an energy of many tens of kilocalories.It is convenient to classify chemical bonding…

The administration of chemical substances for the treatment of disease, especially cancer, or for the prevention of aberrant growth of cells or tissues (neoplasms). In general, chemotherapy is the use of chemicals to treat any disease, but the term…

A chemical element, Cl, atomic number 17 and atomic weight 35.453. Chlorine exists as a greenish-yellow gas at ordinary temperatures and pressures (see illustration). It is second in reactivity only to fluorine among the halogen elements, and hence…

A branch of computer science that deals with the theory and techniques of computer-generated images. Computers produce images by analyzing a collection of dots, or pixels (picture elements). Computer graphics is used to enhance the transfer and…

The response of corals to environmental stress in which they eject the single-cell algae that live within the transparent coral tissue, making the white coral skeleton visible. Corals (Fig. 1) are animals that live in a partnership (symbiosis) with…

The basic quantitative law of electrostatics that quantifies the physical force that exists between two electrically charged points. For electrostatics, Coulomb's law states that the direct force F of point charge q1 on point charge q2, when the…

A genome-engineering technique that allows precise targeting of specific stretches of genetic code and editing of DNA at designated locations. The CRISPR/Cas9 system has been used as a general tool to engineer the genomes of many different…

The interaction of the behavior and ecology of hosts with the biology of pathogens as relating to the impact of diseases on populations. Although human diseases have been studied from an ecological perspective for centuries, diseases in plant and…

A radar system used to measure the relative velocity of targets and their position. The operation of these systems is based on the fact that the Doppler frequency shift in the target echo is proportional to the radial component of target velocity.…

A general term referring to a system or part of a system of conducting parts and their interconnections through which electric currents are intended to flow. A circuit is made up of a voltage source along with active and passive elements, as well as…

The ability of a material to resist or allow the flow of electrical current. Material properties largely determine the resistance and conductance—quantified by electrical resistivity and conductivity—of a given object, such as a circuit or…

The measures of a material's opposition to the flow of electricity and a material's ability to conduct electricity, respectively. Resistivity quantifies resistance, which is a material's opposition to the flow of electrons (an electric current or…

A range of physical phenomena that involve electric charges, their motions, and their effects. In conventional usage, the term “electricity” often refers to the energy that powers lighting, appliances, and other electronic devices in homes,…

The process in which an electron, which has been excited from the valence band to the conduction band of a semiconductor, falls back into an empty state in the valence band, which is known as a hole. When atoms come together to form a crystal, the…

An interdisciplinary science area that is concerned with modeling aspects of natural evolution in order to solve real-world problems of optimization. Living organisms, as well as those that are long extinct, demonstrate optimized complex behavior at…

The use of pollen and spore evidence in legal cases. In its broader application, the field of forensic palynology also includes legal information derived from the analysis of a broad range of microscopic organisms that can be found in both fresh and…

In thermodynamics, the amount of useful work that can be extracted from a closed thermodynamic system. The Helmholtz free energy applies to a process that takes place at a constant temperature T (isothermal process). The Gibbs free energy applies to…

A biological organism whose genetic material has been manipulated artificially through genetic or genomic editing techniques. In contrast to the long history of artificial selection (domestication), in which humans selectively breed organisms to…

An ordered, internally consistent, internationally recognized sequence of time intervals, each distinct in its own history and record of life on Earth, including the assignment of absolute time in years to each geologic interval. The geologic time…

Significant and persistent changes in the state of Earth’s climate. Earth's past climates, or paleoclimates, have alternated between ice ages and periods warmer than today over relatively long time scales (millions to tens of millions of years)…

The rise in the surface temperature of the Earth. Global warming is one of the names given to the systematic increase of globally averaged surface temperature that has been measured since the mid-nineteenth century. There is abundant evidence that…

A phaneritic (visibly crystalline) plutonic rock composed chiefly of sodic plagioclase (oligoclase or andesine), alkali feldspar (microcline or orthoclase, usually perthitic), quartz, and subordinate dark-colored (mafic) minerals (biotite,…

A strongly cemented or hardened (indurated) dark gray sandstone that is characterized by abundant dark-colored detrital rock fragments and more than 15% clay minerals (matrix) between sand grains. The term graywacke evolved from initially informal…

The most common sulfate mineral, characterized by the chemical formula CaSO4 · 2H2O; it shows little variation from this composition.Gypsum is one of the several evaporite minerals. This mineral group includes chlorides, carbonates, borates,…

Pathologies or aberrations in structure or function of blood cells or the blood-clotting mechanism. Hematologic disorders affect the blood and blood-forming organs. Although many diseases and abnormal conditions may be reflected by the blood and its…

A vacant electron energy state near the top of an energy band in a solid. A hole, or more formally an electron hole, represents the absence of an electron where one could exist as part of an atom or within a crystal structure (an atomic lattice)…

A metamorphic rock that has been subjected to heating during contact metamorphism around intrusive igneous rocks. Hornfels is typically fine-grained, although where it is subjected to high temperatures, large crystals called porphyroblasts can form.…

An applied science and technology concerned with the mechanical properties and practical uses of liquids. The physical description of fluids in motion is based upon the conservation laws of mass, momentum, and energy. The mathematical statement of…

One of the three fundamental particles that transmit the weak force. The three intermediate vector bosons are known as the W+, W− , and Z0 particles or bosons. were discovered in 1983 in very high energy proton-antiproton collisions. It is through…

Any scientific law in which a physical quantity varies with distance from a source inversely as the square of that distance. When energy is being radiated by a point source (see illustration), an inverse-square law holds, provided the space between…

A salt or ester of lactic acid (CH3CHOHCOOH). In lactates, the acidic hydrogen of the carboxyl group has been replaced by a metal or an organic radical. Lactates are optically active, with a chiral center at carbon 2. The two optical isomers of a…

A transparent object that uses refraction in order to alter the light that passes through the object. In general, when a ray of light crosses the interface between two different transparent materials, the ray experiences a bending of its path. This…

The spectrum of a beam of light when only a few isolated colors are present. A beam of light (technically, a beam of electromagnetic radiation) typically contains a mixture of pure colors. The particular pure colors that are present in the beam…

An analytical technique for identification of chemical structures, determination of mixtures, and quantitative elemental analysis by measuring the mass-to-charge (m/z) ratio of ions produced when a sample is ionized. Determination of organic and…

A procedure used to remove toxins, fluids, and other substances from the body when the kidneys are unable to handle this removal naturally. In the medical field, medical dialysis is simply referred to as dialysis. The removal of toxins, fluids, and…

A device that is capable of converting chemical energy into electrical energy with the use of whole bacterial cells as the catalyst. Fuels that are produced biologically are known as biofuels. Biofuel cells convert chemical energy from organic…

An autoimmune disease resulting from an abnormality in neuromuscular transmission, characterized by a fluctuating degree of muscle weakness. Myasthenia gravis is a chronic autoimmune neuromuscular disorder (see illustration) characterized by varying…