Search Results

A major plant hormone that plays an important role in plant growth and development. Abscisic acid (ABA), with a chemical formula of C15H20O4 (Fig. 1), is one of the most significant hormones found in plants. It is responsible for regulating various…

Habituation to a specific practice, such as drinking alcoholic beverages or using drugs (for example, heroin, cocaine, or amphetamines), and disorders characterized by the chronic use of a drug, alcohol, or similar substance. Addiction and addictive…

Malfunctions of the paired adrenal glands. The paired adrenal glands are complex endocrine organs in proximity to the kidneys (see illustration), and disorders of the adrenal glands can have serious consequences. Under specific circumstances,…

A disease of the nervous system characterized by a progressive dementia that leads to profound impairment in cognition and behavior. Dementia occurs in a number of brain diseases where the impairment in cognitive abilities represents a decline from…

Loss of sensation with or without loss of consciousness. Anesthesia is used to prevent pain during surgery and other medical procedures. There are several ways of producing anesthesia, with the choice dependent on the type of surgery and the medical…

The formation of new animal individuals, which may occur by asexual or sexual means. All animals must reproduce asexually or sexually to create new individuals of their species. In asexual reproduction, a single parent can produce offspring that are…

An ongoing current event in which a large number of living species are threatened with extinction or are going extinct because of environmentally destructive human activities. The Earth is presently in the midst of a mass extinction event. In the…

Any treatment or procedure that includes the in-vitro handling of oocytes (immature ova or egg cells) and sperm or embryos for the purpose of establishing a pregnancy. Assisted reproductive technology (ART) is undertaken as a treatment of…

A neurodevelopmental condition that impairs the way that a person relates to and communicates with other people. Persons with autism have difficulties with social communication and interaction. They also can have unusual behaviors, such as…

An integrated device consisting of a biological recognition element and a transducer capable of detecting the biological reaction and converting it into a signal that can be processed. Ideally, the sensor should be self-contained, so that it is not…

A hormone, the only known secretory product of the parenchymal or C cells of the mammalian thyroid and of the ultimobranchial glands of lower animal forms. The hormone calcitonin (also referred to as thyrocalcitonin) has been isolated and…

The common name for a malignant neoplasm or tumor. Cancer is a serious medical condition that develops when the orderly relationship of cell division and cell differentiation becomes disordered, leading to the development of neoplasms. Neoplasms are…

Cells within a tumor that possess the capacity to self-renew and cause the heterogeneous lineages of cancerous cells that comprise the tumor. Cancer stem cells (CSCs) typically represent a small percentage of all cells in a tumor (rarely more than…

A firm, resilient connective tissue of vertebrates and some invertebrates. Cartilage (see illustration) is an important structural element found in the bodies of vertebrates and some invertebrates. It is a resistant, elastic connective tissue that…

The mechanism by which cells in a multicellular organism become specialized to perform specific functions in a variety of tissues and organs. Cell differentiation is the process through which cells are transformed into divergent types of cells…

The movement of cells, the movement of materials within cells, and changes in cell shape (including cell division). Cell motility is an important facet of cell biology, encompassing the movement of individual cells, the coordinated movement of many…

The organizing and compartmentation of eukaryotic cells. Eukaryotic cells are divided into several compartments, and each compartment has a characteristic structure, biochemical composition, and function (Fig. 1). These compartments are called…

The field concerning the interactions among cells and molecules of the immune system, and how such interactions contribute to the recognition and elimination of pathogens. Humans (and vertebrates in general) possess a range of nonspecific mechanical…

The administration of chemical substances for the treatment of disease, especially cancer, or for the prevention of aberrant growth of cells or tissues (neoplasms). In general, chemotherapy is the use of chemicals to treat any disease, but the term…

The collective processes by which metabolic materials are transported from one region of an organism to another region. The circulatory system, often termed the cardiovascular system, is responsible for the functions of circulation, allowing…

Pathologies and abnormal conditions that involve the circulatory system. Circulation disorders include both localized disturbances of circulation and diseases of the circulatory system (Fig. 1). Circulation 1 Illustration of the thickening and…

The major fibrous protein in animals. Collagen is present in all types of multicellular animals and is probably the most abundant animal protein in nature. It is estimated that collagen accounts for about 30% of the total human body protein.…

Structural or functional abnormalities of the body that develop during embryogenesis and the fetal period; also called birth defects. Congenital anomalies, or birth defects, are conditions present at or from birth that deviate from the body's normal…

One of the four primary tissues of the body. Connective tissue (Fig. 1) provides the solid foundation required for underpinning, binding, and protecting tissues and organs of the body. Connective tissue differs from the other three tissues…

Any of a group of diseases involving connective tissue as the pathological target. Connective tissue comprises one of the primary tissues of the body and is distinguished by an abundance of fibrillar and nonfibrillar extracellular components, which…

Any of a group of viruses that cause upper and lower respiratory tract diseases, gastroenteritis, hepatitis, and central nervous system infections in birds and mammals, including humans. Coronaviruses (Fig. 1) comprise a major group of common animal…

A genome-engineering technique that allows precise targeting of specific stretches of genetic code and editing of DNA at designated locations. The CRISPR/Cas9 system has been used as a general tool to engineer the genomes of many different…

A member of a class of proteins containing hemes as prosthetic groups that catalyze oxidation–reduction reactions. Cytochromes are heme-containing proteins (see illustration) that play vital roles in electron transport within cells. It should be…

Inflammation of the skin; also known as eczema. Dermatitis, or eczema, is a general medical term that describes irritation or inflammation of the skin. Typically, the inflammation of the skin involves redness and scaling (see illustration). In acute…

The branch of genetics that studies how genes control embryonic development. Advances in the field of developmental genetics have emphasized the degree of conservation throughout evolution of the genes (basic units in inheritance consisting of DNA)…

A deleterious set of responses occurring at the subcellular level, stimulated by infection, injury, or genetic or developmental errors, and manifested in altered structure or functioning of the affected organism. Disease is considered to be a…

Various species of diving, air-breathing animals. Diving animals, which are found in every class of terrestrial vertebrates (amphibians, reptiles, birds, and mammals), are air-breathing species that have almost complete freedom in the aquatic…

A pathology characterized by abnormal enlargement of air spaces distal to the terminal bronchioles in the lung. Emphysema (see illustration) is a pathologic condition distinguished by loss of elasticity of the lung. The primary cause of this loss of…

The study of the glands of internal secretion—the endocrine glands—and the hormones that they synthesize and secrete. Endocrinology is the field of medicine and physiology concerned with the endocrine system, which regulates hormones (chemical…

A family of endogenous peptides with morphinelike action present within the central nervous system. The enkephalins were the first group of endorphins to be identified. They were discovered in 1975 and opened research into a wide number of centrally…

The occurrence of cases of disease in excess of what is usually expected for a given period of time. An epidemic is a breakout of disease affecting unusually large numbers of people within a community or population. When an epidemic spreads…

A hormone, also known as adrenaline, that is an important adrenal secretion. Epinephrine, or adrenaline, is an important secretion from the adrenal medulla (the inner part of the adrenal glands). In 1901, Jokichi Takamine isolated epinephrine in…

The common name for the steroid hormone 17β-estradiol. Estrogen (17β-estradiol; Fig. 1) is an important steroid hormone that aids mammalian sexual and reproductive development. In mammalian females, estrogen maintains secondary sex characters and…

Planets beyond our solar system. For millennia, humankind has known about most of the major planets in our solar system because these worlds are visible to the naked eye. Exoplanets, however, were not indisputably known until 1995, when astronomers…

Disorders of form and function that affect the eye. Eye disorders and diseases are pathological conditions of the eye. Some conditions can result in vision loss and even blindness. In contrast, others are less severe and temporary, being resolved by…

The intentional production of new genes and alteration of genomes by the deletion, substitution, or addition of new genetic material. Genetic engineering involves the artificial recombination of nucleic acid molecules in the test tube; their…

Plants that have altered genetic material (DNA) through recombinant DNA (rDNA) manipulation. Genetic engineering of plants allows for very specific genetic changes to be made to a plant's deoxyribonucleic acid (DNA), as opposed to the random…

Commercially grown plants that have altered genetic material through artificial recombinant manipulation. Genetic modification is the latest scientific tool for developing improved crop varieties. Such genetically modified (GM) crops can help to…

An organism that has had its genetic material manipulated or altered in a laboratory setting through the use of genetic or genomic engineering techniques. Genetically modified organisms (GMOs) are microorganisms, plants, or animals that have been…

Mature cells that have been reprogrammed genetically to an embryonic-like state that then can give rise to one of many different cell types. Induced pluripotent stem cells (iPS cells; Fig. 1) represent a major breakthrough in stem cell research.…

A space telescope mission dedicated to detecting exoplanets. The tenth mission launched under the National Aeronautics and Space Administration's (NASA's) Discovery Program, Kepler was the agency’s first mission dedicated to the search for planets…

The planet fourth outward from the Sun and the planet most like Earth in terms of geology, climate, and suitability for life. Mars is nicknamed the "Red Planet" for its reddish hue (Fig. 1). Besides Earth, Mars is the most-studied world in the solar…

An emerging cancer therapy in which oncolytic viruses are used to target and destroy cancer cells without harming healthy cells. Oncolytic viruses (that is, viruses that destroy cancer cells, but not normal cells) are able to infect, replicate…

Any synthetic or semisynthetic organic chemical compound that resembles opium in its pharmacological action to reduce pain. An opioid is an organic chemical compound, created synthetically or semisynthetically, that duplicates the analgesic…

Any agent capable of causing disease. The term pathogen is usually restricted to living agents or microorganisms that produce disease. Pathogens are infectious and diverse, including bacteria (see illustration), viruses, rickettsia, fungi, yeasts,…

An electron microscope that builds up images of samples via the scanning of the sample's surface with a focused electron beam. The idea of the scanning electron microscope (SEM) dates back to the 1930s, with a great deal of the pioneering…

Cells that have the ability to self-replicate and to give rise to mature cells. The concept of stem cells (Fig. 1) was originally based on renewing tissues. Many adult tissues, including the skin, blood, and intestines, consist of mostly mature and…

An endocrine gland found in all vertebrates that produces, stores, and secretes the thyroid hormones. The primary function of the thyroid gland, in warm-blooded vertebrates at least, is to regulate the rate of metabolism. In humans, the gland is…

Any of the chemical messengers produced by the thyroid gland. For many years, it was generally believed that the thyroid gland produced only two closely related hormones, thyroxine and triiodothyronine. In 1961, though, a new hormonal principle,…

A major body division of the vertebrate trunk lying posterior to the thorax (chest) and, in mammals, bounded anteriorly by the diaphragm and extending to the pelvis. The abdomen (see illustration) is a major anatomical region of the body. The…

The apparent change in direction of a source of light caused by an observer's component of motion perpendicular to the impinging rays.To visualize the effect, first imagine a stationary telescope (illus.a) aimed at a luminous source such as a star,…

The net movement (transport) of water and solutes from outside an organism to its interior. The unidirectional flow of materials into an animal from the environment generally takes place across the alimentary tract, the lungs, or the skin. In each…

An instrument that utilizes focused acoustic waves to produce images of surface and subsurface features in materials, and to measure elastic properties on a microscopic scale. It has been used to image and measure local elastic properties in metals,…

The discipline of acoustic phonetics can be narrowly defined as the study of the acoustic output of the vocal tract for speech, but ultimately it encompasses much more. Acoustic phonetics makes direct contact with, and in many cases is the…

A genus of Gram-negative, immotile and nonspore-forming, oval to rod-shaped, often pleomorphic bacteria that occur as parasites or pathogens in mammals (including humans), birds, and reptiles. Actinobacillus bacteria are facultatively aerobic,…

A nucleotide, composed of ribose, adenine, and a triphosphate group, that is an important energy compound in metabolism. Adenosine triphosphate (ATP) [Fig. 1] is a vital energy-rich chemical found in all living cells. It has a chemical formula of…

A type of connective tissue, especially in mammals, that is specialized for the storage of neutral fats (lipids). Adipose cells originate mainly from fibroblasts (connective tissue cells found in virtually all animal organs). In the mammalian…

A bacterial genus in the family Vibrionaceae comprising oxidase-positive, facultatively anaerobic, monotrichously flagellated Gram-negative rods. The mesophilic species of Aeromonas are A. hydrophila, A. caviae, and A. sobria; the psychrophilic one…

The branch of mathematics dealing with the solution of equations. These equations involve unknowns, or variables, along with fixed numbers from a specified system (Fig. 1). The origins of algebra were based on the need to develop equations that…

The study of zero sets of polynomial equations. Examples of zero sets of polynomial equations studied in algebraic geometry are the parabola y − x2 = 0, thought of as sitting in the (x, y)-plane, and the locus of all points (t, t2, t3, t4), which is…

A regulatory enzyme whose activity is modified by the binding of an activator molecule to an alternate (allosteric) site that is different from the active (catalytic) site. Allosteric enzymes (Fig. 1) are special enzymes involved in regulatory…

Any of the organic compounds possessing one or more basic amino groups and one or more acidic carboxyl groups. Of the more than 80 amino acids that have been found in living organisms, approximately 20 serve as the building blocks for proteins.…

The sum of the biochemical and physiological processes involved in the generation and degradation of amino acids, particularly those utilized as substrates for protein biosynthesis. Amino acid metabolism is a key biological activity undertaken by…

Any of a group of drugs of diverse chemical structure and physiological effects that are used for the relief of pain. Analgesics are drugs, including opiates, synthetic opioids, and salicylates, that are used primarily for pain relief (see…

The closest spiral galaxy to the Milky Way Galaxy. The name of the Andromeda Galaxy (Fig. 1) derives from its appearance in the constellation of Andromeda. The galaxy is also known as M31 and NGC 224, based on its entries in two widely used…

The processes of biological and organic change in animals by which descendants come to differ from their ancestors. Animal evolution encompasses the theory that modern animals are the modified descendants of animals that formerly existed and that…

A small infectious agent that is unable to replicate outside a living animal cell. Animal viruses infect animals and require animal cells as their host. Unlike other intracellular obligatory parasites (for example, chlamydiae and rickettsiae…

A chemical substance, produced by microorganisms, plants, marine organisms, and synthetically, that has the capacity in dilute solutions to inhibit the growth of bacteria or destroy bacteria. Antibiotics are important antibacterial agents. Most are…

The capability that a bacterium acquires to counteract an inhibitory chemical molecule or compound that was formerly effective in killing it or preventing its growth. Antibiotic resistance in bacteria (Fig. 1) is a hot topic in the media and in…

A protein, found principally in blood serum, originating normally or in response to an antigen and characterized by a specific counteracting reactivity with that antigen. Antibodies (Fig. 1) are members of the immunoglobulin class of proteins and…

Any substance that causes the immune system to produce specific antibodies or T cells against it. An antigen may be a foreign substance from the environment (such as chemicals, bacterial or viral proteins, or pollen; Fig. 1) or formed within the…

A reaction that occurs when an antigen combines with a corresponding antibody to produce an immune complex. A substance that induces the immune system to form a corresponding antibody is called an immunogen. All immunogens are also antigens because…

Chemical compounds biosynthetically or synthetically produced that destroy or usefully suppress the growth or metabolism of a variety of microscopic or submicroscopic forms of life. On the basis of their primary activity, antimicrobial agents (see…

The scientific study of past material culture. The initial objective of archeology (often spelled archaeology) is to construct cultural chronologies that order past material culture into meaningful temporal segments. The intermediate objective is to…

A group of diseases affecting joints or their component tissues. Arthritis is the collective term used to describe any joint disorder or process; it also typically involves inflammation. In common usage, arthritis often refers to any joint pain.…

A white, crystalline compound, 1-aspartyl-1-phenylalanine methyl ester (APM), used as an artificial sweetener. Aspartame is composed of two amino acids: aspartic acid and phenylalanine [structure (1)]. Amino acid Artificial sweetener Aspartame…

A nonsteroidal anti-inflammatory drug used to control pain, fever, and inflammation. Aspirin is one of the most prevalent medicines in the world and is used to reduce fever and treat minor aches, pains, and inflammation. Furthermore, it is the only…

The most common type of arrhythmia (any disorder of the heart rate or rhythm). Atrial fibrillation, often abbreviated AFib or AF, is a heart condition that can lead to potentially serious complications. It is associated with decreased quality of…

The processes of both the increase in number and the increase in mass of bacteria. The net growth in a population of bacteria (Fig. 1) depends on its ability to produce new biomass, to produce new cells incorporating that biomass, and to survive…

The study of bacteria. The science of bacteriology is a specialized branch of microbiology concerned with bacteria (Fig. 1). Although bacteria are different in some important respects from all other kinds of cells, their basic processes of…

The study of the hereditary factors that shape behavior. Behavior genetics, that is, the scientific investigation of the hereditary factors that influence behavior, may be studied in animals and humans. Charles Darwin, who originated the theory that…

The study of behavior change in response to drugs, chemicals, or other environmental conditions or agents. Behavioral toxicology investigates the effect of toxic exposure on organismal behavior. The toxic exposure can involve various chemicals,…

The study of the substances and chemical processes that occur in living organisms. Biochemistry is a shortening of the term biological chemistry. It is a scientific discipline that investigates the chemical compounds and reactions that take place…

The destruction of organic compounds by microorganisms. Biodegradation is a process (carried out by microorganisms) that decomposes organic material into its constituent elements or new compounds. Microorganisms, particularly bacteria (and fungi to…

A microbial (often bacterial) community that is enveloped by an adhesive substance (the glycocalyx) at the interface of a liquid and a surface. Biofilms (see illustration) are defined as highly structured communities of microorganisms that are…

The emission of light by living organisms that is visible to other organisms. Bioluminescence (see illustration) does not come from or depend on light absorbed by the organism. It derives from an enzymatically catalyzed chemiluminescence, that is, a…

The application of principles from applied and physical sciences to problems in healthcare and biology. As a field, biomedical engineering draws from a variety of disciplines including mechanical, chemical, electrical, and computer engineering, as…

A form of terrorism in which there is the intentional release of biological agents (viruses, bacteria, fungi, or toxins) from living organisms or agents in order to cause death or disease in humans, animals, and/or plants; also referred to as…

The practice of fertility control, including contraception, which is intended to prevent pregnancy, and the means of interrupting early pregnancy. The efficacy of the various methods of birth control and their consistency of use vary widely (see…

A fluid connective tissue that circulates in the vascular system (blood vessels) of the body. Blood circulates through the body via vascular blood vessels (arteries, veins, and capillaries). Blood consists of plasma (the fluid component) and cells…

Any of the tubular channels for blood transport, of which there are three principal types: arteries, capillaries, and veins. Blood circulates through the body via blood vessels, which include the arteries, veins, and capillaries. These structures…

The hard connective tissue that, together with cartilage, forms the skeleton of humans and other vertebrates. Bone (Fig. 1) is made of calcium phosphate crystals arranged on a protein scaffold and performs a variety of functions. For example, it has…

A genus of pathogenic gram-negative bacteria that are coccobacilli and obligate aerobes, and fail to ferment carbohydrates. Bordetella bacteria are respiratory pathogens. Bordetella pertussis, B. parapertussis, and B. bronchiseptica share greater…

Either of the two human mammary glands, usually well developed in the adult female, but rudimentary in the male. Breast is the common term used for the human mammary gland. This structure is particularly important in the adult female because it…

A gravitationally bound, condensed body whose mass is too small to sustain nuclear fusion reactions in its core. Brown dwarfs are often likened to "failed stars." The approximate mass range for brown dwarfs is between 13 and 80 times the mass of…