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A common medicine used to relieve mild to moderate pain and reduce fever. Acetaminophen (N-acetyl-p-aminophenol), or paracetamol, is a white crystalline compound with the molecular formula C8H9NO2 (Fig. 1). It is a member of the aniline family of…

A disease of the nervous system characterized by a progressive dementia that leads to profound impairment in cognition and behavior. Dementia occurs in a number of brain diseases where the impairment in cognitive abilities represents a decline from…

Any of the cells within a tumor that possess the capacity to self-renew and cause the heterogeneous lineages of cancerous cells that comprise the tumor. Cancer stem cells (CSCs) typically represent a small percentage of all cells in a tumor (rarely…

Any clouding or opacity of the crystalline lens of the eye. Loss of the transparency of the lens (see illustration) prevents the normal passage of light onto the light-sensitive retina at the back of the eye and thus a loss of visual ability.…

The administration of chemical substances for the treatment of disease, especially cancer, or for the prevention of aberrant growth of cells or tissues (neoplasms). In general, chemotherapy is the use of chemicals to treat any disease, but the term…

A genome-engineering technique that allows precise targeting of specific stretches of genetic code and editing of DNA at designated locations. The CRISPR/Cas9 system has been used as a general tool to engineer the genomes of many different…

The interaction of the behavior and ecology of hosts with the biology of pathogens as relating to the impact of diseases on populations. Although human diseases have been studied from an ecological perspective for centuries, diseases in plant and…

The adaptation of an animal or plant through breeding in captivity to a life intimately associated with and advantageous to humans. Domesticated plants and animals differ genetically and morphologically from their wild counterparts, often in ways…

A biological organism whose genetic material has been manipulated artificially through genetic or genomic editing techniques. In contrast to the long history of artificial selection (domestication), in which humans selectively breed organisms to…

A space-traversing unmanned vehicle which contains the means for controlling its flight path and that delivers an explosive warhead with high accuracy. Various kinds of missiles are guided in the sense that they can aerodynamically adjust after…

Pathologies or aberrations in structure or function of blood cells or the blood-clotting mechanism. Hematologic disorders affect the blood and blood-forming organs. Although many diseases and abnormal conditions may be reflected by the blood and its…

The process of tissue death (necrosis) resulting from a failure of blood supply and lack of oxygen (anoxia) reaching the tissue's cells. The usual cause of infarction is occlusion (blockage or closing) of an artery by a thrombus (blood clot; see…

The entrance, growth, and multiplication of a microorganism or pathogen in the body of a host. Infection may or may not result in the establishment of a disease process, depending on many variables including the pathogen involved, the health of the…

A disease caused by members of the protozoan genus Plasmodium (a widespread group of protists that parasitize the human liver and red blood cells) and transmitted by the bite of the female Anopheles mosquito. Malaria is a serious mosquito-borne…

A procedure used to remove toxins, fluids, and other substances from the body when the kidneys are unable to handle this removal naturally. In the medical field, medical dialysis is simply referred to as dialysis. The removal of toxins, fluids, and…

An autoimmune disease resulting from an abnormality in neuromuscular transmission, characterized by a fluctuating degree of muscle weakness. Myasthenia gravis is a chronic autoimmune neuromuscular disorder (see illustration) characterized by varying…

A progressive degenerative disorder of the nervous system belonging to a group of conditions called motor system disorders. Parkinson's disease—more specifically known as idiopathic Parkinson's disease to distinguish it from the four Parkinson-plus…

In medicine and health sciences, a value expected for an individual whose state of health is known and well described, and the interval of values broadly expected for a population, respectively. Results of clinical laboratory tests and other…

A clinical condition caused by widespread impairment of blood flow resulting in an inadequate supply of oxygen to the body's tissues and organs. Shock is a response to hypoperfusion, which is the inadequate circulation of blood throughout the body.…

A rare genetic disorder in which there is a deficiency of hexosaminidase A (a lysosomal enzyme that hydrolyzes GM2 gangliosides). Tay-Sachs disease is a severe and progressive neurodegenerative disease. Because of the deficiency of hexosaminidase A…

The process of forming a thrombus, which is a solid mass or plug in the living heart or vessels composed of the constituents of the blood. Thrombosis usually occurs in a diseased blood vessel, as a result of arteriosclerosis. The consequences of…

An aqueous solution of organic and inorganic substances—mostly waste products of metabolism—that collects in the kidneys and is removed from the body primarily through the urinary bladder and urinary tract. Urine is a liquid waste produced by the…

Diseases that are transmitted from animals to humans. Zoonoses (the singular form is zoonosis) are also termed zoonotic diseases. They are infectious diseases passed from animals (Fig. 1) to humans. Zoonotic agents are found among all major…

A viral disease of humans caused by the human immunodeficiency virus (HIV), which attacks and compromises the body's immune system. Individuals infected with the human immunodeficiency virus (HIV) proceed through a spectrum of stages that ultimately…

Habituation to a specific practice, such as drinking alcoholic beverages or using drugs (for example, heroin, cocaine, or amphetamines), and disorders characterized by the chronic use of a drug, alcohol, or similar substance. Addiction and addictive…

Malfunctions of the paired adrenal glands. The paired adrenal glands are complex endocrine organs in proximity to the kidneys (see illustration), and disorders of the adrenal glands can have serious consequences. Under specific circumstances,…

The repeated and/or excessive use of alcohol (ethanol) that continues despite negative physical, psychiatric, or social consequences. Alcoholism is characterized by consuming alcohol more often, in larger amounts, or over longer periods than…

Any of the organic compounds possessing one or more basic amino groups and one or more acidic carboxyl groups. Of the more than 80 amino acids that have been found in living organisms, approximately 20 serve as the building blocks for proteins.…

A class of steroid hormones produced in the testes and adrenal cortex that act to regulate masculine secondary sexual characteristics. The major naturally occurring androgens, such as testosterone, are C-19 steroids (that is, they each contain 19…

A synthetic manufactured drug derived from the male sex hormone testosterone. Androgenic-anabolic steroids, often termed simply as anabolic steroids, are artificially produced testosterone variants. They can provide a number of medical benefits when…

Loss of sensation with or without loss of consciousness. Anesthesia is used to prevent pain during surgery and other medical procedures. There are several ways of producing anesthesia, with the choice dependent on the type of surgery and the medical…

The use of live nonhuman animals for scientific research and experimentation. Animal testing has been a cornerstone of biomedical research, having contributed greatly to the understanding of human biology, to the unraveling of the complex underlying…

A type of drug that inhibits the combination of histamine with histamine receptors. Antihistamine drugs are termed either H-1 or H-2 receptor antagonists, depending on which type of histamine receptor is involved. H-1 receptor antagonists are used…

The application of chemical techniques to the study of archeological materials in order to elucidate aspects of the human past. The materials used in archeological chemistry might be anthropogenic (for example, pottery or metal) or natural (from…

Any treatment or procedure that includes the in-vitro handling of oocytes (immature ova or egg cells) and sperm or embryos for the purpose of establishing a pregnancy. Assisted reproductive technology (ART) is undertaken as a treatment of…

A highly contagious intestinal disease, also known as shigellosis, caused by rod-shaped bacteria of the genus Shigella. Bacillary dysentery, which also is referred to as shigellosis, is a significant intestinal infection. Rod-shaped bacteria of the…

Any of a group of drugs used for the suppression of anxiety, the induction of sleep, and the control of seizures. Barbiturates are sedative-hypnotic drugs, derived from barbituric acid, that act as central nervous system depressants (see…

The drug as well as the plant known as deadly nightshade (Atropa belladonna). The belladonna plant (Atropa belladonna; see illustration) belongs to the nightshade family, Solanaceae, in the order Solanales. The plant is a coarse and poisonous…

The study of skeletal remains from archeological sites by biological (or physical) anthropologists. Bioarcheology differs in several ways from traditional skeletal research (see illustration). Previous work focused on individual case studies (for…

A biological product used to induce immunity to various infectious diseases or noxious substances of biological origin. Biological products, or simply biologicals, are usually limited to immune serums, antitoxins, vaccines (see illustration), and…

Identifying exposure sources, routes, frequency, duration, and magnitude using biomarker data combined with other approaches, such as computational models and available environmental measurement data. The goal of environmental health science is to…

The application of chemical engineering principles to the solution of medical problems due to physiological impairment. Knowledge of organic chemistry is required of all chemical engineers, and many study biochemistry and molecular biology. This…

An integrated device consisting of a biological recognition element and a transducer capable of detecting the biological reaction and converting it into a signal that can be processed. Ideally, the sensor should be self-contained, so that it is not…

Malignant and benign lesions of the human mammary glands. Breast cancer and other breast disorders are potentially serious medical conditions. Benign breast disorders are often symptomatic and bothersome, but do not have malignant potential.…

A rare inflammatory lung disease affecting the small airways (bronchioles) and air sacs (alveoli) of the respiratory system. Bronchiolitis obliterans organizing pneumonia (BOOP) was first described in 1985 by Gary Epler as a disease distinct from…

An infectious disease of various animals and humans caused by Brucella bacteria. Brucellosis (also known as Malta fever, Mediterranean fever, and undulant fever) is a significant disease of many animals. It affects numerous mammals, primarily…

The common name for a malignant neoplasm or tumor. Cancer is a serious medical condition that develops when the orderly relationship of cell division and cell differentiation becomes disordered, leading to the development of neoplasms. Neoplasms are…

A genus comprising yeasts that cause a variety of human diseases referred to as candidiasis. All Candida species are single-celled yeasts (fungal organisms) that are ovoid in shape and 3–5 μm in size, and they multiply by a process called budding.…

Any of the group of organic compounds consisting of carbon, hydrogen, and oxygen that includes sugars, starches, and cellulose. Carbohydrate compounds consist of carbon, hydrogen, and oxygen, with the general chemical formula Cm(H2O)n [Fig. 1]; the…

A condition caused by the thickening of ligaments and tendon sheaths at the wrist, with consequent compression of the median nerve at the palm. The carpal tunnel is a thin passageway among ligaments and tendon sheaths located in the wrist joint area…

A re-emerging arthropod-borne viral (arboviral) disease that is most often characterized by the sudden onset of high fever and severe joint pain (arthralgia), which can persist for years following acute illness. Chikungunya viruses are usually…

An illness of unknown cause and uncertain prevalence, often resulting in debilitating fatigue accompanied by diverse symptoms. Chronic fatigue syndrome (CFS) is a complicated and disabling illness. Characterized by extreme degrees of fatigue (see…

A lung condition that is characterized by limitation of airflow from the lungs and manifests with shortness of breath, cough, and sputum production. Chronic obstructive pulmonary disease (COPD) is a significant cause of disease and death. COPD is…

Pathologies and abnormal conditions that involve the circulatory system. Circulation disorders include both localized disturbances of circulation and diseases of the circulatory system (Fig. 1). Circulation 1 Illustration of the thickening and…

A branch of clinical pathology concerned with the role of the immune defense system in disease. The subject of clinical immunology encompasses diseases where a malfunction of the immune system itself is the basic cause, together with diseases where…

The adaptation of microbiological techniques to the study of the etiological agents of infectious disease. Clinical microbiology, also termed medical microbiology, is a branch of science concerned with the investigation of pathogenic microorganisms…

A Gram-positive, anaerobic, spore-forming bacterium that causes a severe form of antibiotic-associated diarrhea. Clostridioides difficile (formerly Clostridium difficile and often abbreviated as C. diff) [Fig. 1] is a rod-shaped bacterium…

An infectious viral disease of the upper respiratory system characterized by inflammation of the mucus membranes of the nose, throat, eyes, and eustachian tubes, leading to watery mucus production that turns purulent (containing pus). Common colds…

Structural or functional abnormalities of the body that develop during embryogenesis and the fetal period; also called birth defects. Congenital anomalies, or birth defects, are conditions present at or from birth that deviate from the body's normal…

Any of a group of diseases involving connective tissue as the pathological target. Connective tissue comprises one of the primary tissues of the body and is distinguished by an abundance of fibrillar and nonfibrillar extracellular components, which…

Any of a group of viruses that cause upper and lower respiratory tract diseases, gastroenteritis, hepatitis, and central nervous system infections in birds and mammals, including humans. Coronaviruses (Fig. 1) comprise a major group of common animal…

A laboratory test performed prior to a blood transfusion to determine whether donor blood is compatible with the recipient's blood. Choosing a blood donor who is compatible with the recipient is vital. Therefore, crossmatching between the donor and…

The use of data analytics and informatics-based approaches to discriminate between potential environmental contaminants and noncontaminants. New and emerging environmental contaminants are chemicals that have not been previously detected or that are…

A medical disorder in humans that results from a sudden reduction in atmospheric pressure. Decompression illness—also called decompression sickness, dysbarism, caisson disease, the bends, and compressed-air illness—is a physiological condition…

Disorders characterized by the gradual and progressive loss of nerve cells. Degenerative neural diseases, or neurodegenerative diseases (see illustration), are pathological conditions that result in the progressive degeneration or death of neurons…

A syndrome characterized by a generalized decline in cognition that is severe enough to cause functional impairment in daily activities. Dementia is a term used to describe a collection of symptoms of severe cognitive decline. Individuals suffering…

A mosquito-borne viral infection throughout the world's tropical and subtropical zones. Dengue fever (also known as breakbone fever and dandy fever) is an acute viral disease of humans characterized by fever, rash, prostration, and lymphadenopathy.…

Inflammation of the skin; also known as eczema. Dermatitis, or eczema, is a general medical term that describes irritation or inflammation of the skin. Typically, the inflammation of the skin involves redness and scaling (see illustration). In acute…

Any of various abnormal metabolic conditions characterized by excessive levels of sugar glucose in the blood and tissues of the body, as well as excessive urinary output, thirst, and hunger; in common usage, usually refers to diabetes mellitus.…

The passage of loose or watery stools, usually at more frequent than normal intervals. Diarrhea is characterized by more-frequent and abnormally loose or watery stools (greater than 227 g or 8 oz per 24 h). The two principal mechanisms responsible…

An acute infectious disease of humans caused by Corynebacterium diphtheriae. Diphtheria is a contagious and potentially life-threatening infectious disease. The causative agent is the bacterium Corynebacterium diphtheriae (see illustration).…

A deleterious set of responses occurring at the subcellular level, stimulated by infection, injury, or genetic or developmental errors, and manifested in altered structure or functioning of the affected organism. Disease is considered to be a…

A system that delivers controlled amounts of a therapeutic agent over a prolonged period or in a desirable temporal fashion, thereby maintaining required plasma or tissue drug levels. Drug delivery systems are bioengineered mechanisms or devices…

Underdevelopment and overdevelopment of the skeleton, respectively. Dwarfism and gigantism are conditions of abnormal skeletal growth. In general, skeletal growth is a complex process and can be disturbed in many ways. For example, overstimulation…

Any of a group of exotic viral agents that cause a severe hemorrhagic fever disease in humans and other primates. The six known subtypes or species of Ebola viruses are Zaire, Sudan, Bundibugyo, Taï Forest or Côte d'Ivoire (Ivory Coast), Reston, and…

A diagnostic procedure that uses ultrasound at a frequency of 2.5–10 MHz to provide an image of the heart. Echocardiography is a methodology that employs high-frequency sound waves (ultrasound) to create images of the heart (see illustration). The…

A pathology characterized by abnormal enlargement of air spaces distal to the terminal bronchioles in the lung. Emphysema (see illustration) is a pathologic condition distinguished by loss of elasticity of the lung. The primary cause of this loss of…

A Chemical compound that interferes with the proper function of endocrine systems in humans and other organisms. There has been much scientific and medical research on pharmaceuticals as endocrine disruptors. However, endocrine disruptors are…

The study of the production, fate, and effects of natural and synthetic pollutants in the environment. The breadth of this field depends on the definition of environment. It can be defined as narrowly as the home and workplace or as broadly as the…

The occurrence of cases of disease in excess of what is usually expected for a given period of time. An epidemic is a breakout of disease affecting unusually large numbers of people within a community or population. When an epidemic spreads…

Occurrences of disease cases in excess of normal expectancy caused by the bacterium Escherichia coli. Outbreaks of disease resulting from Escherichia coli (E. coli) contamination have serious consequences. However, most strains of E. coli bacteria…

An active and intentional act or practice of putting to death, in a relatively painless way, of persons suffering severely from medical conditions that are incurable, untreatable, or irreversible. Euthanasia is an act by a person, usually a…

The test of a hypothesis under controlled conditions. The experiment is one of the distinctive tools of the scientist. It enables the scientist to put questions to nature and receive answers. These answers lead to new problems whose solutions…

Disorders of form and function that affect the eye. Eye disorders and diseases are pathological conditions of the eye. Some conditions can result in vision loss and even blindness. In contrast, others are less severe and temporary, being resolved by…

Lenses worn to improve vision. Eyeglasses and contact lenses are eyewear devices used to correct or improve defective eyesight (see illustration). The primary function of the eye is to focus light energy on the retina. In the optics of a normal eye,…

A principal type of connective-tissue cell. Fibroblasts are large, flat, stellate or spindle-shaped connective-tissue cells found in virtually all animal organs (see illustration). They constitute the most common type of cells in mammalian…

A yellow vitamin, slightly soluble in water, which is usually found in conjugates containing varying numbers of glutamic acid residues. Folic acid (C19H19N7O6; see illustration) belongs to the B family of vitamins. Also known as pteroylglutamic acid…

A tickborne bacterial disease of pregnant cattle, characterized by late-term abortion or birth of stillborn calves or weak calves that do not survive. Foothill abortion, also termed epizootic bovine abortion (EBA), is an economically devastating…

A hypersensitivity or altered reactivity caused by fungal allergens. More than 20% of the population in industrialized countries suffers from allergic disease, and diverse allergens (substances foreign to the body that cause allergy) associated with…

The common name for a group of perennial herbs in the genus Panax cultivated for the aromatic root of the plant, which is used medicinally in China. Herbal members of the genus Panax belong to the aralia family (Araliaceae) and are native to…

Optical instruments that establish an optical line or axis for the purpose of aiming a weapon. The axis includes the observer's eye, a suitable mark in the instrument, and the target. For a pistol, the traditional iron sights employ a rear notch and…

A branch of the environmental and occupational safety health sciences and professions concerned with the protection of people and the environment from possibly harmful effects of radiation, while providing for the utilization of radiation for the…

Pathologies of the heart and its blood vessels. The heart is the muscular pumping organ of the cardiovascular system of vertebrates (Fig. 1). However, a diseased or defective heart can have serious consequences. Almost all cardiovascular or heart…

High blood pressure. Hypertension occurs when there is a state of abnormally elevated blood pressure. Blood pressure is expressed in two numbers (see illustration): the higher number is the systolic blood pressure, which is the pressure exerted by…

A tentative supposition with regard to an unknown state of affairs, the truth of which is thereupon subject to investigation by any available method, either by logical deduction of consequences which may be checked against what is known, or by…

A means for estimating the potential for environmental damage that may be caused by a product or process, ideally before the product or process begins. Life-cycle assessment (LCA) includes all of the steps from extracting natural resources through…

An interdisciplinary field for preventing occupational illnesses and injuries. The disciplines of engineering, epidemiology, toxicology, medicine, psychology, and sociology provide the methods for study and prevention. Occupational hazards Tens of…

Any of several low, perennial, tropical South American shrubs or half-shrubs in the family Rubiaceae. Ipecac plants (also termed ipecacuanha plants) are native to the tropical forests of Brazil and Colombia. Several species are used, but the dried…

An arachnid taxon comprising the ticks. Ticks are arachnids (Fig. 1). Specifically, they are members of the Ixodida, which is considered to be an order or suborder (depending on the exact classification) of the subclass Acari (Acarina) in the class…

Intentional generation of interfering signals in the electromagnetic spectrum by powerful transmitters as a countermeasure intended to block a communication, radar, or infrared system or to impair its effectiveness appreciably. Radio broadcasts or…