Unfolded protein response
Schröder, Martin School of Biological and Biomedical Sciences, Durham University, Durham, United Kingdom.
Last reviewed:January 2021
- Signal transduction by the UPR
- Physiology and pathophysiology of the UPR
- Related Primary Literature
- Additional Reading
A collective term for the signal transduction pathways that are activated by inhibition of protein folding in the endoplasmic reticulum (the location where newly synthesized, completely unfolded polypeptide chains fold into their native conformation), thereby coordinating adaptive responses to this stress situation. The unfolded protein response leads to increased synthesis of folding and degradative enzymes, as well as decreasing overall new protein synthesis, allowing the endoplasmic reticulum to better handle the load of unfolded protein. See also: Endoplasmic reticulum; Enzyme; Protein; Protein folding; Signal transduction
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