Type 1 diabetes
Homann, Dirk Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, Colorado.
Last reviewed:April 2021
Show previous versions
- Natural history of type 1 diabetes
- Prediction, prevention, and reversion of type 1 diabetes
- Management of type 1 diabetes
- Related Primary Literature
- Additional Reading
An abnormal metabolic condition in which the pancreas produces little or no insulin and characterized by excessive levels of sugar glucose in the blood and tissues of the body. Type 1 diabetes (T1D; formerly termed insulin-dependent or juvenile diabetes) [Fig. 1] is an autoimmune disease that poses significant challenges to afflicted individuals, to the development of effective therapeutic interventions, and to public health initiatives at large. Although the precise interactions between inherited susceptibilities and environmental factors that together trigger the disease remain to be elucidated in detail, development of type 1 diabetes is mediated by complex autoimmune processes that eventually destroy insulin-secreting beta cells in the pancreas and lead to elevated blood sugar levels along with serious disturbances of protein, fat, and carbohydrate metabolism. Currently, no cure or effective prevention is available. Despite insulin treatment, severe complications, including kidney failure, heart attack, and stroke, are frequent. See also: Autoimmunity; Carbohydrate metabolism; Diabetes; Energy metabolism; Glucose; Insulin; Lipid metabolism; Metabolic disorders; Metabolism; Pancreas; Pancreas disorders; Public health; Type 2 diabetes
The content above is only an excerpt.
for your institution. Subscribe
To learn more about subscribing to AccessScience, or to request a no-risk trial of this award-winning scientific reference for your institution, fill in your information and a member of our Sales Team will contact you as soon as possible.
to your librarian. Recommend
Let your librarian know about the award-winning gateway to the most trustworthy and accurate scientific information.
AccessScience provides the most accurate and trustworthy scientific information available.
Recognized as an award-winning gateway to scientific knowledge, AccessScience is an amazing online resource that contains high-quality reference material written specifically for students. Contributors include more than 10,000 highly qualified scientists and 46 Nobel Prize winners.
MORE THAN 8700 articles covering all major scientific disciplines and encompassing the McGraw-Hill Encyclopedia of Science & Technology and McGraw-Hill Yearbook of Science & Technology
115,000-PLUS definitions from the McGraw-Hill Dictionary of Scientific and Technical Terms
3000 biographies of notable scientific figures
MORE THAN 19,000 downloadable images and animations illustrating key topics
ENGAGING VIDEOS highlighting the life and work of award-winning scientists
SUGGESTIONS FOR FURTHER STUDY and additional readings to guide students to deeper understanding and research
LINKS TO CITABLE LITERATURE help students expand their knowledge using primary sources of information