Treffers, Henry P. Formerly, Department of Pathology, School of Medicine, Yale University, New Haven, Connecticut.
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In serology, the combination of a toxic antigen with its corresponding antitoxin. If the antitoxin is derived from any species other than the horse, precipitation occurs over a wide range of reactant ratios, as in other antigen-antibody reactions. With horse antitoxin, flocculation occurs only if toxin and antitoxin are near equivalence, a twofold excess of either reactant giving soluble complexes. In most instances, the reaction results in partial or complete neutralization of the toxic activity of the antigen. See also: Antigen; Antitoxin; Neutralization reaction (immunology); Toxin
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