DISCLAIMER: This article is being kept online for historical purposes. Though accurate at last review, it is no longer being updated. The page may contain broken links or outdated information.
Solid-state NMR spectroscopy
Offerdahl, Thomas J. University of Kansas, Lawrence, Kansas.
Munson, Eric J. Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, Kansas.
- Solid-state analysis
- Quantitation of drug forms
- Related Primary Literature
- Additional Reading
The processing and formulation (dosage form) of a drug may affect important pharmaceutical properties, such as form purity (whether the drug contains polymorphic or amorphous content, which might make it less therapeutically active), dissolution characteristics, chemical and physical stability, and bioavailability. Although it currently is not widely used for the characterization of pharmaceutical formulations, solid-state nuclear magnetic resonance (NMR) spectroscopy is a powerful technique that is useful for studying pharmaceutical materials. Because the spectrum for each polymorphic/amorphous form is often unique, the NMR method makes it possible to identify the state of the drug as well as the inactive ingredients used in drugs (excipients). Peaks from excipients are usually in a different region (chemical shift or frequency) of the NMR spectrum than are the peaks from drugs.
The content above is only an excerpt.
for your institution. Subscribe
To learn more about subscribing to AccessScience, or to request a no-risk trial of this award-winning scientific reference for your institution, fill in your information and a member of our Sales Team will contact you as soon as possible.
to your librarian. Recommend
Let your librarian know about the award-winning gateway to the most trustworthy and accurate scientific information.
AccessScience provides the most accurate and trustworthy scientific information available.
Recognized as an award-winning gateway to scientific knowledge, AccessScience is an amazing online resource that contains high-quality reference material written specifically for students. Contributors include more than 9000 highly qualified scientists and 43 Nobel Prize winners.
MORE THAN 8700 articles covering all major scientific disciplines and encompassing the McGraw-Hill Encyclopedia of Science & Technology and McGraw-Hill Yearbook of Science & Technology
115,000-PLUS definitions from the McGraw-Hill Dictionary of Scientific and Technical Terms
3000 biographies of notable scientific figures
MORE THAN 19,000 downloadable images and animations illustrating key topics
ENGAGING VIDEOS highlighting the life and work of award-winning scientists
SUGGESTIONS FOR FURTHER STUDY and additional readings to guide students to deeper understanding and research
LINKS TO CITABLE LITERATURE help students expand their knowledge using primary sources of information