Sensory cell regeneration
Lanford, Pamela National Institute on Deafness and Other Communication Disorders, Rockville, Maryland.
Coffin, Allison Aquatic Bioacoustics Laboratory, University of Maryland, College Park, Maryland.
- Receptor cells
- Innate regenerative capabilities
- Therapeutic regenerative strategies
- Notch signaling pathway
- Proneural genes
- Links to Primary Literature
- Additional Readings
The replacement of receptor cells within sensory end organs (retina, cochlea, taste buds, olfactory epithelium), most commonly via addition of newly differentiated cells to the systems. Humans and other organisms use a variety of sensory receptors to detect and interpret information from the surrounding environment. These receptors may be damaged by environmental toxins, injury, or overstimulation, thereby reducing the sensory input received by the organism and the animal's ability to respond appropriately to stimuli. In some systems, such as taste, new sensory receptors are produced on a regular basis. In others, including hearing in humans, the loss of sensory cells is permanent. This article briefly describes the major classes of sensory receptors in vertebrates and some mechanisms of receptor cell regeneration.
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