Temin, Howard M. Formerly, McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin Medical School, Madison, Wisconsin. Nobelist.
- Genetic information flow
- Virus classification
- DNA provirus
- Properties of reverse transcriptase
- Mechanisms of synthesis of retrovirus DNA
- Related Primary Literature
- Additional Reading
Any of the deoxyribonucleic acid (DNA) polymerases present in particles of retroviruses, that is, in virions of ribonucleic acid (RNA) tumor viruses and related viruses. These DNA polymerases are coded by the retroviruses and are able to carry out DNA synthesis using an RNA template. This reaction is called reverse transcription since it is the opposite of the usual transcription reaction, which involves RNA synthesis using a DNA template. Thus, the viral DNA polymerases that carry out this reverse reaction have been called reverse transcriptases, and the viruses with this enzyme are called retroviruses because they reverse the usual flow of genetic information. Such viruses are much discussed now, since the etiologic agent of acquired immune deficiency syndrome (AIDS) is a retrovirus. See also: Acquired immune deficiency syndrome (AIDS); Retrovirus
The content above is only an excerpt.
for your institution. Subscribe
To learn more about subscribing to AccessScience, or to request a no-risk trial of this award-winning scientific reference for your institution, fill in your information and a member of our Sales Team will contact you as soon as possible.
to your librarian. Recommend
Let your librarian know about the award-winning gateway to the most trustworthy and accurate scientific information.
AccessScience provides the most accurate and trustworthy scientific information available.
Recognized as an award-winning gateway to scientific knowledge, AccessScience is an amazing online resource that contains high-quality reference material written specifically for students. Contributors include more than 10,000 highly qualified scientists and 45 Nobel Prize winners.
MORE THAN 8700 articles covering all major scientific disciplines and encompassing the McGraw-Hill Encyclopedia of Science & Technology and McGraw-Hill Yearbook of Science & Technology
115,000-PLUS definitions from the McGraw-Hill Dictionary of Scientific and Technical Terms
3000 biographies of notable scientific figures
MORE THAN 19,000 downloadable images and animations illustrating key topics
ENGAGING VIDEOS highlighting the life and work of award-winning scientists
SUGGESTIONS FOR FURTHER STUDY and additional readings to guide students to deeper understanding and research
LINKS TO CITABLE LITERATURE help students expand their knowledge using primary sources of information