Mescher, Anthony L. Anatomy Section, School of Medicine, Medical Sciences Program, Indiana University, Bloomington, Indiana.
Last reviewed:August 2019
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- Tissue and organ regeneration in mammals
- Musculoskeletal system
- Central nervous system
- Role of the immune system
- Limb regeneration in amphibians
- Impact of metamorphosis
- Role of electric currents
- Artificial induction of limb regeneration in vertebrates
- Morphogenesis during limb regeneration
- Tail regeneration
- Regeneration in invertebrates
- Related Primary Literature
- Additional Reading
The field within developmental biology that focuses on regeneration, that is, the process by which an animal restores a lost part of its body. Regenerative biology is concerned with the regenerative capacity of cells, tissues, and organs. Broadly defined, the term regeneration can include many kinds of restorative activities shown by a wide variety of organisms. However, regeneration in this context connotes reproduction of a more perfect or complete replacement of a missing tissue or organ than usually results from processes of tissue repair or wound healing (Fig. 1). For example, cells of the epidermis, blood, and digestive and reproductive tracts are regenerated continuously or periodically in all vertebrates. Within the field of developmental biology, however, most research in regeneration involves systems in which removing a complex structure or major part of an organism initiates a chain of events that produces a structure that duplicates the missing part both functionally and anatomically. See also: Cell (biology); Cell biology; Developmental biology; Organ regeneration; Restoring regeneration; Sensory cell regeneration
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