Yalow, Rosalyn S. Formerly, Albert Einstein College of Medicine, Yeshiva University, New York, New York. Nobelist.
Cohen, J. John Department of Immunology, University of Colorado Medical School, Aurora, Colorado.
Last reviewed:January 2020
- Substances measured
- Competitive radioassay
- Sensitivity considerations
- Nonspecific interference
- Related Primary Literature
- Additional Reading
A general method employing the reaction of antigen with specific antibody, permitting measurement of the concentration of virtually any substance of biologic interest, often with unparalleled sensitivity. The basis of the method is summarized in the competing reactions shown in Fig. 1. The unknown concentration of the antigenic substance in a sample is obtained by comparing its inhibitory effect on the binding of radioactively labeled antigen to a limited amount of specific antibody with the inhibitory effect of known standards.
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