Dilworth, S. M. MRC Laboratory of Molecular Biology, Cambridge, United Kingdom.
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A papovavirus (member of a DNA-containing group of animal viruses) that infects rodents. This virus can induce a wide variety of tumors when inoculated into newborn animals. The simple structure has made the virus a popular model for the study of lytic infection (a viral infection that results in the lysis of the host cell and release of viral progeny) by animal viruses, and viral-induced tumorigenesis (tumor formation). As a result, much is known of the biology of this virus. Discoveries made through studying its action have influenced the work on most other cancers. See also: Tumor viruses
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