Dorn, Gerald W., II Division of Biology and Biomedical Sciences, Washington University, St. Louis, Missouri.
Last reviewed:June 2020
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- Mitochondria and mitophagy
- Parkin and PINK1
- Mitochondrial quality control
- Related Primary Literature
- Additional Reading
A regulatory pathway that maintains mitochondrial integrity. The PINK1-Parkin pathway plays a significant role in mitochondrial quality control by providing a mechanism for the elimination of damaged and aging mitochondria. This multifaceted pathway maintains mitochondrial homeostasis through the actions of two proteins: PINK1 [PTEN (phosphatase and tensin homolog)–induced kinase-1] and Parkin (see illustration). See also: Aging; Mitochondria; Protein; Protein kinase
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