Hanson, Allen L. Formerly, Department of Chemistry, Saint Olaf College, Northfield, Minnesota.
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One of a general class of medicinals known variously as analgesics, antifebrins, or antipyretics, of which acetanilide is the best known. Phenacetin is an acetyl derivative of p-phenetidine. It is made by the reaction of with C2H5Cl to form which is reduced to the corresponding amine and acetylated to form phenacetin, The reaction is continued as a cyclic process in which phenol, acetic acid, and ethyl chloride are continuously supplied. Phenacetin is less toxic than acetanilide, but it lowers the ability of blood to combine with oxygen. See also: Hypothermia
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