Tuite, Paul Department of Neurology, University of Minnesota, Minneapolis, Minnesota.
Last reviewed:March 2019
Show previous versions
- Related Primary Literature
- Additional Reading
A progressive degenerative disorder of the nervous system belonging to a group of conditions called motor system disorders. Parkinson's disease results in the loss of brain cells that produce dopamine. The cause of this progressive degenerative disorder of the nervous system is unknown (Fig. 1), but specific environmental and genetic factors are increasingly being evaluated for their role in the disease. Parkinson's disease typically begins in middle age, with an average age of onset of 59 years, but it also can begin in the 30s or 40s as well as in the 70s or later. Males are affected slightly more commonly than females; all ethnic groups can develop the disease, with Caucasians at somewhat higher risk. Typically, Parkinson's disease is sporadic, but it can occur in familial clusters; moreover, research on some of these families has resulted in the discovery of a few genetic mutations. To date, however, genetic testing is not usually performed due to the low chance of finding a genetic cause for an affected individual. See also: Brain; Degenerative neural diseases; Dopamine; Genetics; Motor systems; Mutation; Nervous system (vertebrate); Nervous system disorders
The content above is only an excerpt.
for your institution. Subscribe
To learn more about subscribing to AccessScience, or to request a no-risk trial of this award-winning scientific reference for your institution, fill in your information and a member of our Sales Team will contact you as soon as possible.
to your librarian. Recommend
Let your librarian know about the award-winning gateway to the most trustworthy and accurate scientific information.
AccessScience provides the most accurate and trustworthy scientific information available.
Recognized as an award-winning gateway to scientific knowledge, AccessScience is an amazing online resource that contains high-quality reference material written specifically for students. Contributors include more than 10,000 highly qualified scientists and 46 Nobel Prize winners.
MORE THAN 8700 articles covering all major scientific disciplines and encompassing the McGraw-Hill Encyclopedia of Science & Technology and McGraw-Hill Yearbook of Science & Technology
115,000-PLUS definitions from the McGraw-Hill Dictionary of Scientific and Technical Terms
3000 biographies of notable scientific figures
MORE THAN 19,000 downloadable images and animations illustrating key topics
ENGAGING VIDEOS highlighting the life and work of award-winning scientists
SUGGESTIONS FOR FURTHER STUDY and additional readings to guide students to deeper understanding and research
LINKS TO CITABLE LITERATURE help students expand their knowledge using primary sources of information