Pandemic of 1918
Pierce, Marcia M. Department of Biological Sciences, Eastern Kentucky University, Richmond, Kentucky.
- Spanish flu pandemic
- Bioengineering a newly virulent influenza virus
- Future outlook
- Links to Primary Literature
- Additional Readings
The Spanish influenza pandemic of 1918–1919 is considered the most devastating outbreak of infectious disease in recorded history. In fact, the Spanish flu killed more people in a period of 25 weeks than acquired immune deficiency syndrome (AIDS) has killed in 25 years. Conservative estimates place the number of fatalities at 20 million; others believe that the number may be as many as 50 million within a very short time frame. This pandemic is sometimes called the “forgotten” pandemic because of the way it has passed out of the collective consciousness. The pandemic was caused by an unusually severe and virulent strain of the influenza A virus subtype H1N1. Recently, scientists bioengineered genes from the original chromosome of the 1918 influenza virus into template influenza viruses that had very limited capability of causing disease. Genes for two of the major proteins in influenza virus were used: hemagglutinin (HA) and neuraminidase (NA). It was found that the HA protein made these viruses highly lethal in mice, which previously had not developed disease after being infected with the template virus. Further studies in macaques found that much of the damage results from the host's immune response, which causes a “cytokine storm” in the patient. These results suggest that the primary reason for the pandemic's severity was the virulent proteins of the virus and not the conditions of the era in which it occurred.
The content above is only an excerpt.
for your institution. Subscribe
To learn more about subscribing to AccessScience, or to request a no-risk trial of this award-winning scientific reference for your institution, fill in your information and a member of our Sales Team will contact you as soon as possible.
to your librarian. Recommend
Let your librarian know about the award-winning gateway to the most trustworthy and accurate scientific information.
AccessScience provides the most accurate and trustworthy scientific information available.
Recognized as an award-winning gateway to scientific knowledge, AccessScience is an amazing online resource that contains high-quality reference material written specifically for students. Contributors include more than 9000 highly qualified scientists and 43 Nobel Prize winners.
MORE THAN 8700 articles covering all major scientific disciplines and encompassing the McGraw-Hill Encyclopedia of Science & Technology and McGraw-Hill Yearbook of Science & Technology
115,000-PLUS definitions from the McGraw-Hill Dictionary of Scientific and Technical Terms
3000 biographies of notable scientific figures
MORE THAN 19,000 downloadable images and animations illustrating key topics
ENGAGING VIDEOS highlighting the life and work of award-winning scientists
SUGGESTIONS FOR FURTHER STUDY and additional readings to guide students to deeper understanding and research
LINKS TO CITABLE LITERATURE help students expand their knowledge using primary sources of information