Whitcomb, David C. Division of Gastroenterology, Heptology, and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Stewart, Andrew F. Division of Endocrinology and Metabolism, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Norris, H. Thomas Department of Clinical Pathology and Diagnostic Medicine, School of Medicine, East Carolina University, Greenville, North Carolina.
Last reviewed:June 2019
Show previous versions
- Congenital disorders
- Cystic fibrosis
- Links to Primary Literature
- Additional Readings
Pathologies of the pancreas. The pancreas (Fig. 1) is affected by a variety of congenital and acquired diseases. These diseases can have grave consequences because the pancreas is a gland with three types of cells that serve three different functions. Acinar cells produce digestive enzymes, duct cells produce a bicarbonate-rich fluid, and islet of Langerhans cells produce insulin and other hormones that regulate nutrient-associated metabolism. Disorders occur when normal function of the pancreas is disrupted through germline mutations [mutations within a lineage of cells forming the gametes (sex or germ cells)], acquired mutations [genetic changes limited to somatic (body) cells, and a major cause of cancer], injury, or inflammation. See also: Enzyme; Gland; Hormone; Inflammation; Insulin; Metabolism; Mutation; Pancreas
The content above is only an excerpt.
for your institution. Subscribe
To learn more about subscribing to AccessScience, or to request a no-risk trial of this award-winning scientific reference for your institution, fill in your information and a member of our Sales Team will contact you as soon as possible.
to your librarian. Recommend
Let your librarian know about the award-winning gateway to the most trustworthy and accurate scientific information.
AccessScience provides the most accurate and trustworthy scientific information available.
Recognized as an award-winning gateway to scientific knowledge, AccessScience is an amazing online resource that contains high-quality reference material written specifically for students. Contributors include more than 9000 highly qualified scientists and 43 Nobel Prize winners.
MORE THAN 8700 articles covering all major scientific disciplines and encompassing the McGraw-Hill Encyclopedia of Science & Technology and McGraw-Hill Yearbook of Science & Technology
115,000-PLUS definitions from the McGraw-Hill Dictionary of Scientific and Technical Terms
3000 biographies of notable scientific figures
MORE THAN 19,000 downloadable images and animations illustrating key topics
ENGAGING VIDEOS highlighting the life and work of award-winning scientists
SUGGESTIONS FOR FURTHER STUDY and additional readings to guide students to deeper understanding and research
LINKS TO CITABLE LITERATURE help students expand their knowledge using primary sources of information