Shors, Teri Department of Biology and Microbiology, University of Wisconsin, Oshkosh, Wisconsin.
Last reviewed:January 2021
- Traditional cancer treatment
- Discovery of oncolytic viruses
- Oncolytic viruses and clinical trials
- Using recombinant poliovirus to kill glioblastoma
- Approval of poliovirus therapy
- Future of virotherapy to treat cancer
- Related Primary Literature
- Additional Reading
An emerging cancer therapy in which oncolytic viruses are used to target and destroy cancer cells without harming healthy cells. Oncolytic viruses (that is, viruses that destroy cancer cells, but not normal cells) are able to infect, replicate inside of, and kill cancer cells through diverse mechanisms. The viral infection also stimulates the body's immune system to eliminate the infected cancer cells, potentially causing malignant tumors to shrink. As such, oncolytic virotherapy or oncolytic virus therapy holds great potential as a prominent tool to combat cancer (see illustration). See also: Cancer; Cell (biology); Oncology; Tumor; Virus
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