Cole, Michael Department of Molecular Biology, Princeton University, Princeton, New Jersey.
Last reviewed:February 2019
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- Genetic basis of neoplasia
- Mechanisms of oncogene formation
- Viral oncogenes
- Oncogene functions
- Oncogene-targeted cancer therapy
- Links to Primary Literature
- Additional Readings
Genes that contribute to the conversion of a normal cell into a cancerous cell. Oncogenes are defective genes that can cause a cell to divide in an unregulated manner, leading to cancer. Oncogenes can derive from cellular genes that undergo mutations that alter their expression or activity, or from viruses that carry oncogenes within their genome and are transferred into the cell by infection (Fig. 1). See also: Animal virus; Cancer; Cancer cell metabolism; Cell (biology); Cell division; Gene; Mutation; Oncology; Virus
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