New drug to control tuberculosis
Pierce, Marcia M. Department of Biological Sciences, Eastern Kentucky University, Richmond, Kentucky.
- PA-824 and its mechanism of action
- Links to Primary Literature
- Additional Readings
Tuberculosis is a disease that infects approximately one-third of the world's population. Many individuals have latent tuberculosis, in which they are infected with Mycobacterium tuberculosis, but the bacterium is dormant in the lungs, causing no signs of infection. Latent infection is difficult to treat because the bacteria are not dividing while they exist in this dormant state. Antimicrobial drugs work to kill bacteria when they are actively growing and multiplying; latent tuberculosis cannot, therefore, be treated effectively until the bacteria begin to multiply. A new drug, PA-824, produces nitric oxide (NO) gas when it is metabolized inside the bacterial cell. This gas can kill the bacterium from within, “exploding” it and causing bacterial death even when the bacterium is not multiplying, which may in turn lead to new and effective treatments for latent tuberculosis.
The content above is only an excerpt.
for your institution. Subscribe
To learn more about subscribing to AccessScience, or to request a no-risk trial of this award-winning scientific reference for your institution, fill in your information and a member of our Sales Team will contact you as soon as possible.
to your librarian. Recommend
Let your librarian know about the award-winning gateway to the most trustworthy and accurate scientific information.
AccessScience provides the most accurate and trustworthy scientific information available.
Recognized as an award-winning gateway to scientific knowledge, AccessScience is an amazing online resource that contains high-quality reference material written specifically for students. Contributors include more than 9000 highly qualified scientists and 43 Nobel Prize winners.
MORE THAN 8700 articles covering all major scientific disciplines and encompassing the McGraw-Hill Encyclopedia of Science & Technology and McGraw-Hill Yearbook of Science & Technology
115,000-PLUS definitions from the McGraw-Hill Dictionary of Scientific and Technical Terms
3000 biographies of notable scientific figures
MORE THAN 19,000 downloadable images and animations illustrating key topics
ENGAGING VIDEOS highlighting the life and work of award-winning scientists
SUGGESTIONS FOR FURTHER STUDY and additional readings to guide students to deeper understanding and research
LINKS TO CITABLE LITERATURE help students expand their knowledge using primary sources of information