Horwich, Arthur Yale University School of Medicine, Howard Hughes Medical Institute, New Haven, Connecticut.
Fenton, Wayne Yale University, New Haven, Connecticut.
- Protein folding
- Other functions
- Links to Primary Literature
- Additional Readings
A specialized cellular protein that binds nonnative forms of other proteins and assists them to reach a functional conformation, in most cases through the expenditure of adenosine triphosphate (ATP). Originally identified by their increased abundance after heat shock, chaperone proteins in general bind to exposed hydrophobic surfaces of nonnative proteins, preventing them from forming intermolecular interactions that lead to irreversible multimolecular aggregation. Thus, the role of chaperone proteins under conditions of stress, such as heat shock, is to protect proteins by binding to incipiently misfolded conformations, preventing aggregation; then, following return of normal conditions, they allow refolding to occur, associated with protein release. See also: Adenosine triphosphate (ATP); Protein
The content above is only an excerpt.
for your institution. Subscribe
To learn more about subscribing to AccessScience, or to request a no-risk trial of this award-winning scientific reference for your institution, fill in your information and a member of our Sales Team will contact you as soon as possible.
to your librarian. Recommend
Let your librarian know about the award-winning gateway to the most trustworthy and accurate scientific information.
AccessScience provides the most accurate and trustworthy scientific information available.
Recognized as an award-winning gateway to scientific knowledge, AccessScience is an amazing online resource that contains high-quality reference material written specifically for students. Contributors include more than 9000 highly qualified scientists and 43 Nobel Prize winners.
MORE THAN 8700 articles covering all major scientific disciplines and encompassing the McGraw-Hill Encyclopedia of Science & Technology and McGraw-Hill Yearbook of Science & Technology
115,000-PLUS definitions from the McGraw-Hill Dictionary of Scientific and Technical Terms
3000 biographies of notable scientific figures
MORE THAN 19,000 downloadable images and animations illustrating key topics
ENGAGING VIDEOS highlighting the life and work of award-winning scientists
SUGGESTIONS FOR FURTHER STUDY and additional readings to guide students to deeper understanding and research
LINKS TO CITABLE LITERATURE help students expand their knowledge using primary sources of information