Mitosis and the spindle assembly checkpoint
DeLuca, Jennifer G. Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado.
- Mechanics of mitosis
- Spindle assembly checkpoint
- Links to Primary Literature
- Additional Readings
Mitosis is the process that produces new cells through the replication and division of existing cells. Multicellular organisms such as humans require mitotic cell division for development and growth, and to continually replenish dying cells. Prior to mitosis, the cellular genetic material (DNA), which is organized into chromosomes, is replicated to produce two sister chromatids that remain joined until late mitosis. During mitosis, each sister chromatid pair (that is, replicated chromosome) aligns at the cell equator. Then, the two sister chromatids are pulled apart, thus forming two daughter chromosomes, and are segregated to opposite sides of the cell. The cell is finally halved, resulting in the production of two identical cells from one. Mitosis must be tightly regulated to ensure that the resulting daughter cells have exactly one copy of each chromosome, because missegregated chromosomes are implicated in the initiation and progression of cancer, as well as in the formation of birth defects in humans. The safety mechanism responsible for monitoring mitotic division is known as the spindle assembly checkpoint (SAC) and has evolved to ensure that chromosome segregation occurs faithfully.
The content above is only an excerpt.
for your institution. Subscribe
To learn more about subscribing to AccessScience, or to request a no-risk trial of this award-winning scientific reference for your institution, fill in your information and a member of our Sales Team will contact you as soon as possible.
to your librarian. Recommend
Let your librarian know about the award-winning gateway to the most trustworthy and accurate scientific information.
AccessScience provides the most accurate and trustworthy scientific information available.
Recognized as an award-winning gateway to scientific knowledge, AccessScience is an amazing online resource that contains high-quality reference material written specifically for students. Contributors include more than 9000 highly qualified scientists and 43 Nobel Prize winners.
MORE THAN 8700 articles covering all major scientific disciplines and encompassing the McGraw-Hill Encyclopedia of Science & Technology and McGraw-Hill Yearbook of Science & Technology
115,000-PLUS definitions from the McGraw-Hill Dictionary of Scientific and Technical Terms
3000 biographies of notable scientific figures
MORE THAN 19,000 downloadable images and animations illustrating key topics
ENGAGING VIDEOS highlighting the life and work of award-winning scientists
SUGGESTIONS FOR FURTHER STUDY and additional readings to guide students to deeper understanding and research
LINKS TO CITABLE LITERATURE help students expand their knowledge using primary sources of information