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Ramkrishna, Doraiswami School of Chemical Engineering, Purdue University, West Lafayette, Indiana.
Song, Hyun-Seob Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington.
- Issues with metabolic network analysis
- Steady-state analyses
- Dynamic metabolic models
- Related Primary Literature
A metabolic network is the set of chemical reactions that takes place within a cell. These reactions, which together constitute what is known as metabolism, help cells to grow, reproduce, and maintain their structure, composition, and function. Nutrient molecules that enter the cell through the cell membrane undergo numerous reactions, each of which is catalyzed by a specific enzyme that must also be synthesized by the cell. The initial breakdown of energy-carrying nutrients is called catabolism, which produces a diverse variety of key biochemical constituents such as amino acids, lipids, carbohydrates, nucleotides, and energy-carrying molecules such as ATP, ADP, and NADPH. The use of building blocks to synthesize new biomass and other metabolic products is called anabolism. See also: Cell (biology); Enzyme; Metabolism
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