King, Donald West, Jr. Department of Pathology, University of Chicago, Chicago, Illinois.
Last reviewed:June 2018
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- Internal metabolic control mechanisms
- Nucleic acids
- Links to Primary Literature
- Additional Readings
Pathologies of metabolism principally involving an imbalance in nucleic acids, proteins, lipids, or carbohydrates. Metabolic disorders occur when abnormal biochemical reactions disrupt the normal processes of metabolism. In general, metabolic disorders are usually associated with either a biochemical deficiency or excess that results in an imbalance in a particular metabolic pathway (Fig. 1). All metabolic disorders have a genetic background, and some of them are expressed as specific genetic diseases. Metabolic processes throughout life are strongly influenced by the genetic component of aging, by diet, and by various types of environmental injury, including infectious agents (for example, bacteria, viruses, fungi, and parasites), physical agents (for example, radiation and temperature), and chemical agents in the environment. See also: Amino acid metabolism; Carbohydrate metabolism; Energy metabolism; Genetics; Lipid metabolism; Metabolism
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