Immune complex disease
Cole, Edward H. Department of Immunopathology, Scripps Clinic and Research Foundation, La Jolla, California.
Wilson, Curtis B. Department of Immunopathology, Scripps Clinic and Research Foundation, La Jolla, California.
- Human immune complex disease
- Links to Primary Literature
- Additional Readings
Local or systemic tissue injury caused by the vascular deposition of products of antigen-antibody interaction, termed immune complexes. Immune complex formation with specific antibodies causes the inactivation of potentially dangerous antigenic substances and their elimination by phagocytic cells. There are harmful consequences only when immune complexes deposit in tissues, inciting various mediators of inflammation, leading to injury and disease. When the reaction takes place in the extravascular fluids near the site of origin of the antigen (by injection, secretion, and such), focal injury can occur, as exemplified by the Arthus reaction or such conditions as experimental immune thyroiditis. Systemic disease may occur when soluble antigens combine with antibodies in the vascular compartment, forming circulating immune complexes that are trapped nonspecifically in the vascular beds of various organs, causing such clinical diseases as serum sickness or systemic lupus erythematosus with vasculitis and glomerulonephritis. The term immune complex disease usually signifies this systemic immune complex formation and vascular deposition. In the widely used classification originated by Gell and Coombs, immune complex disease is Type III immunopathology. See also: Connective tissue disease
The content above is only an excerpt.
for your institution. Subscribe
To learn more about subscribing to AccessScience, or to request a no-risk trial of this award-winning scientific reference for your institution, fill in your information and a member of our Sales Team will contact you as soon as possible.
to your librarian. Recommend
Let your librarian know about the award-winning gateway to the most trustworthy and accurate scientific information.
AccessScience provides the most accurate and trustworthy scientific information available.
Recognized as an award-winning gateway to scientific knowledge, AccessScience is an amazing online resource that contains high-quality reference material written specifically for students. Contributors include more than 9000 highly qualified scientists and 43 Nobel Prize winners.
MORE THAN 8500 articles and Research Reviews covering all major scientific disciplines and encompassing the McGraw-Hill Encyclopedia of Science & Technology and McGraw-Hill Yearbook of Science & Technology
115,000-PLUS definitions from the McGraw-Hill Dictionary of Scientific and Technical Terms
3000 biographies of notable scientific figures
MORE THAN 19,000 downloadable images and animations illustrating key topics
ENGAGING VIDEOS highlighting the life and work of award-winning scientists
SUGGESTIONS FOR FURTHER STUDY and additional readings to guide students to deeper understanding and research
LINKS TO CITABLE LITERATURE help students expand their knowledge using primary sources of information