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HIV and bone marrow transplantation
Shors, Teri Department of Biology and Microbiology, University of Wisconsin, Oshkosh, Wisconsin.
- HIV patient background
- Acute myeloid leukemia: a curse or a blessing?
- A special bone marrow donor
- A stunning but risky medical breakthrough
- Is Timothy Ray Brown cured?
- The future: CCR5 deletion gene therapy
- Related Primary Literature
- Additional Reading
This article chronicles a novel treatment that saved a patient from two different diseases, one of which was thought to be incurable. The patient was infected with human immunodeficiency virus (HIV) and also suffered from acute myeloid leukemia (AML). Based on research known about HIV's interactions with T-cells, doctors tailored the patient's treatment to not only be an effective cancer treatment for AML but also a treatment to cure the patient's HIV infection. HIV infects T-cells, which are specialized immune cells that are depleted as the course of HIV infection progresses in the patient. The patient received a bone marrow transplantation from a donor who had a natural resistance to HIV infection. Bone marrow transplantation is also part of the protocol to treat leukemia patients in addition to chemotherapy and radiation treatment.
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