Hippo pathway (developmental biology)
Varelas, Xaralabos Department of Biochemistry, Boston University Medical Center, Boston, Massachusetts.
- The core signaling cascade and downstream transcriptional regulation
- Upstream regulation of Taz/Yap
- The Hippo pathway in development: stem cell control
- Dysregulation of the Hippo pathway
- Links to Primary Literature
- Additional Readings
An important cell signaling pathway mediating cell fate determination, tissue growth, and organ homeostasis. Tissue development and organ development rely on the accurate coordination of intrinsic and extrinsic cellular cues. Dynamic changes in these signals dictate the context in which cells proliferate, move, die, and are specified. The Hippo pathway has emerged as a central mediator of such decisions, functioning to integrate mechanical cues with growth factor signaling. Defective Hippo pathway activity is implicated in a variety of diseases, most notably cancer. Thus, considerable effort is being directed toward understanding the effects of inappropriate Hippo pathway activation and discerning how conventional signals become dysregulated. See also: Cell (biology); Cell differentiation; Cell fate determination; Developmental biology; Molecular biology; Signal transduction
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