Hedgehog signaling proteins
Wu, Xiaofeng Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas.
Lum, Lawrence Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas.
- Building the Hh pathway using fruit flies
- Atypical molecular switches gate Hh pathway activity
- Cellular tower and Hh signal transduction
- Management of cancer with Hh pathway inhibitors
- Links to Primary Literature
- Additional Readings
An understanding of the molecular programs that control the formation of specific cell types in complex multicellular organisms is essential for therapeutic efforts focused on improving tissue regeneration and disabling cancerous cell growth. The success in characterizing these programs in the last few decades has been largely built on genetic results using the embryonic development of model organisms, such as fruit flies and mice, to identify genes that control cell differentiation. The creation of specific cell types, such as muscle, fat, and blood cells, is a coordinated process dependent on different cellular precursors communicating cell differentiation cues to one another. Perhaps not surprisingly then, many of these molecular programs are controlled by secreted proteins (proteins released from cells) that transmit intercellular signals between neighboring or distant cells. The secreted Hedgehog (Hh) signaling molecule is essential for embryonic patterning and the formation of the limbs and central nervous system. Frequently, as a consequence of genetic mutations, the cellular responses controlled by the Hh protein can be exploited to promote cancerous cell growth. Based on this understanding, chemicals that inhibit these cellular responses have been developed for the treatment of certain forms of skin and brain cancers. This brief overview of the Hh pathway will describe its inception from efforts to understand the molecular basis of development and its remarkable journey to therapeutic relevance in cancer.
The content above is only an excerpt.
for your institution. Subscribe
To learn more about subscribing to AccessScience, or to request a no-risk trial of this award-winning scientific reference for your institution, fill in your information and a member of our Sales Team will contact you as soon as possible.
to your librarian. Recommend
Let your librarian know about the award-winning gateway to the most trustworthy and accurate scientific information.
AccessScience provides the most accurate and trustworthy scientific information available.
Recognized as an award-winning gateway to scientific knowledge, AccessScience is an amazing online resource that contains high-quality reference material written specifically for students. Contributors include more than 9000 highly qualified scientists and 43 Nobel Prize winners.
MORE THAN 8500 articles and Research Reviews covering all major scientific disciplines and encompassing the McGraw-Hill Encyclopedia of Science & Technology and McGraw-Hill Yearbook of Science & Technology
115,000-PLUS definitions from the McGraw-Hill Dictionary of Scientific and Technical Terms
3000 biographies of notable scientific figures
MORE THAN 19,000 downloadable images and animations illustrating key topics
ENGAGING VIDEOS highlighting the life and work of award-winning scientists
SUGGESTIONS FOR FURTHER STUDY and additional readings to guide students to deeper understanding and research
LINKS TO CITABLE LITERATURE help students expand their knowledge using primary sources of information