Timoney, John F. Department of Veterinary Science, University of Kentucky, Lexington, Kentucky.
Last reviewed:January 2020
Show previous versions
- Epidemiology and transmission
- Clinical findings and pathology
- Diagnosis and treatment
- Control and prevention
- Related Primary Literature
- Additional Reading
A contagious zoonosis affecting primarily horses, mules, and donkeys and caused by the bacterium Burkholderia mallei. Glanders primarily involves the respiratory systems, skin, and lymphatics. It is marked by a purulent inflammation of mucous membranes and an eruption of nodules on the skin, forming deep ulcers (see illustration). Glanders was once common throughout the world, but now is found only in the Middle East and parts of Africa, Russia, Asia, and South America. Burkholderia mallei (formerly known as Pseudomonas mallei) is a gram-negative, non-acid-fast, nonsporulating, nonmotile, unencapsulated bacillus occasionally showing bipolar staining; it is obligately aerobic and oxidase-positive. It is closely related to B. pseudomallei, the cause of melioidosis, a disease of humans and animals in Southeast Asia and northern Australia. Burkholderia mallei is highly infectious for humans, who may acquire it by handling or treating glanderous animals or during laboratory investigations. Untreated acute disease in humans has a 95% mortality rate within 3 weeks. There is no vaccine against infection. Burkholderia mallei is considered a category B biological agent because it is moderately easy to disseminate, causes moderate morbidity with high mortality in untreated cases, and requires special enhanced laboratory diagnostic capability. See also: Bioterrorism; Disease; Donkeys and allies; Horse production; Infectious disease; Medical bacteriology; Mule; Perissodactyla; Zoonoses
The content above is only an excerpt.
for your institution. Subscribe
To learn more about subscribing to AccessScience, or to request a no-risk trial of this award-winning scientific reference for your institution, fill in your information and a member of our Sales Team will contact you as soon as possible.
to your librarian. Recommend
Let your librarian know about the award-winning gateway to the most trustworthy and accurate scientific information.
AccessScience provides the most accurate and trustworthy scientific information available.
Recognized as an award-winning gateway to scientific knowledge, AccessScience is an amazing online resource that contains high-quality reference material written specifically for students. Contributors include more than 10,000 highly qualified scientists and 45 Nobel Prize winners.
MORE THAN 8700 articles covering all major scientific disciplines and encompassing the McGraw-Hill Encyclopedia of Science & Technology and McGraw-Hill Yearbook of Science & Technology
115,000-PLUS definitions from the McGraw-Hill Dictionary of Scientific and Technical Terms
3000 biographies of notable scientific figures
MORE THAN 19,000 downloadable images and animations illustrating key topics
ENGAGING VIDEOS highlighting the life and work of award-winning scientists
SUGGESTIONS FOR FURTHER STUDY and additional readings to guide students to deeper understanding and research
LINKS TO CITABLE LITERATURE help students expand their knowledge using primary sources of information