Genomics of depression
Sibille, Etienne Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania.
- Major depressive disorder
- Genomic approach
- Links to Primary Literature
- Additional Readings
Depression has been characterized recently as “a heterogeneous disorder with a highly variable course, an inconsistent response to treatment, and no established mechanism.” This alarming characterization for the disease that is the leading worldwide cause of years lost as a result of disability potentially reflects a fundamental flaw in previous experimental approaches that have focused on few candidate biological systems to understand the pathology of the illness. Recent genome-wide or “genomic” approaches depart from these traditional investigations because they rely on the unbiased knowledge of the whole genome to identify changes in the structure or function of genes in association with the disease.
The content above is only an excerpt.
for your institution. Subscribe
To learn more about subscribing to AccessScience, or to request a no-risk trial of this award-winning scientific reference for your institution, fill in your information and a member of our Sales Team will contact you as soon as possible.
to your librarian. Recommend
Let your librarian know about the award-winning gateway to the most trustworthy and accurate scientific information.
AccessScience provides the most accurate and trustworthy scientific information available.
Recognized as an award-winning gateway to scientific knowledge, AccessScience is an amazing online resource that contains high-quality reference material written specifically for students. Contributors include more than 9000 highly qualified scientists and 43 Nobel Prize winners.
MORE THAN 8500 articles and Research Reviews covering all major scientific disciplines and encompassing the McGraw-Hill Encyclopedia of Science & Technology and McGraw-Hill Yearbook of Science & Technology
115,000-PLUS definitions from the McGraw-Hill Dictionary of Scientific and Technical Terms
3000 biographies of notable scientific figures
MORE THAN 19,000 downloadable images and animations illustrating key topics
ENGAGING VIDEOS highlighting the life and work of award-winning scientists
SUGGESTIONS FOR FURTHER STUDY and additional readings to guide students to deeper understanding and research
LINKS TO CITABLE LITERATURE help students expand their knowledge using primary sources of information