Geyer, Pamela K. Department of Biochemistry, University of Iowa, Iowa City, Iowa.
Li, Xingguo Department of Biochemistry, University of Iowa, Iowa City, Iowa.
Last reviewed:August 2015
- Transcriptional gene silencing depends on chromatin structure
- Regulation in euchromatin: Establishment and maintenance of transcriptional gene silencing
- Establishment and propagation of heterochromatin: Long-range gene silencing
- Posttranscriptional gene silencing
- Links to Primary Literature
- Additional Readings
Regulation of gene expression via mechanisms that include suppression at transcriptional and posttranscriptional levels. Development requires the precise orchestration of complex patterns of gene expression that ultimately determine cell identity. Unique gene expression profiles are achieved through the integration of regulatory inputs from extrinsic and intrinsic factors that selectively activate or repress target genes. In multicellular organisms, gene silencing plays a major role in the regulation of gene expression, occurring at transcriptional and posttranscriptional levels. See also: Gene
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