Crameri, Reto Department of Molecular Allergology, Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
Rhyner, Claudio Department of Molecular Allergology, Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
- Epidemiology, prevalence, and clinical relevance
- Diagnosis and recombinant fungal allergens
- Links to Primary Literature
- Additional Readings
Hypersensitivities or altered reactivities caused by fungal allergens (substances foreign to the body that cause allergy). Over 20% of the population in industrialized countries suffers from allergic disease, and a wide number of allergenic sources associated with different forms of allergy have been reported. Among these, fungal allergens play a predominant role because they cover more than 17% of all allergen structures known to induce immunoglobulin E (IgE)–mediated sensitization. [IgE is one of the body's five classes (isotypes) of immunoglobulins (any of the glycoproteins in the blood serum that are induced in response to invasion by foreign antigens and that protect the host by eradicating pathogens; antibodies belong to this group of proteins).] In contrast to pollen allergens, which show a typical seasonal variation, fungal allergens are present in the environment all year long and often in far greater concentrations than pollen grains during the seasonal peak. See also: Immunoglobulin
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