Washington, M. Todd Department of Biochemistry, University of Iowa, Iowa City, Iowa.
Last reviewed:May 2018
Show previous versions
- Enzyme inhibition and metabolic regulation
- Enzyme inhibitors as pharmacologic agents
- Types of enzyme inhibition
- Related Primary Literature
- Additional Reading
Prevention of an enzymatic process as a result of the interaction of some substance with the enzyme so as to decrease the rate of reaction. Enzymes, which are usually protein macromolecules, catalyze nearly all of the metabolic reactions in cells. Enzyme inhibition is the general process by which the rate that an enzyme catalyzes a reaction is reduced (Fig. 1). The agent causing the reduction in enzyme activity is called the inhibitor; inhibitors are usually small-molecule chemical compounds, but are, on occasion, other protein macromolecules. Enzyme inhibition is an important phenomenon in biochemistry because it is the basis for much of metabolic regulation. It also is important for medicine because many pharmacologic agents work by inhibiting enzymes. See also: Allosteric enzyme; Biochemistry; Bioorganic chemistry; Catalysis and catalysts; Enzyme; Medicine; Metabolism; Protein
The content above is only an excerpt.
for your institution. Subscribe
To learn more about subscribing to AccessScience, or to request a no-risk trial of this award-winning scientific reference for your institution, fill in your information and a member of our Sales Team will contact you as soon as possible.
to your librarian. Recommend
Let your librarian know about the award-winning gateway to the most trustworthy and accurate scientific information.
AccessScience provides the most accurate and trustworthy scientific information available.
Recognized as an award-winning gateway to scientific knowledge, AccessScience is an amazing online resource that contains high-quality reference material written specifically for students. Contributors include more than 9000 highly qualified scientists and 43 Nobel Prize winners.
MORE THAN 8700 articles covering all major scientific disciplines and encompassing the McGraw-Hill Encyclopedia of Science & Technology and McGraw-Hill Yearbook of Science & Technology
115,000-PLUS definitions from the McGraw-Hill Dictionary of Scientific and Technical Terms
3000 biographies of notable scientific figures
MORE THAN 19,000 downloadable images and animations illustrating key topics
ENGAGING VIDEOS highlighting the life and work of award-winning scientists
SUGGESTIONS FOR FURTHER STUDY and additional readings to guide students to deeper understanding and research
LINKS TO CITABLE LITERATURE help students expand their knowledge using primary sources of information