DISCLAIMER: This article is being kept online for historical purposes. Though accurate at last review, it is no longer being updated. The page may contain broken links or outdated information.
Timp, Gregory Beckman Institute, University of Illinois, Urbana, Illinois.
- Nanopore sensors
- Synthetic nanopores
- Related Primary Literature
- Additional Reading
Nanometer-diameter pores, known as ion channels, are vital to biology, as they are used to regulate the flow of molecules or ions through the otherwise impermeable nanometer-thick membranes that encompass and isolate cells from their environment. The pores can act like switches, opening and closing in response to chemistry through the binding of a ligand, in response to electricity associated with the membrane potential near the pore, or mechanically through deformation in the membrane. This regulatory motif has been observed in action. Modulation of the ionic current through a single nanopore associated with the salt water in the environment of a cell has been observed using a patch clamp pioneered in Nobel-prize winning work by B. Sakmann and E. Neher. A patch clamp consists of a glass micropipette filled with electrolyte that is in contact with a chlorinated silver wire conducting electricity to a low-noise amplifier. The open tip of the macropipette, which is about 1 micrometer in diameter, is sealed to a portion of a cell membrane containing a pore to record the current through it.
The content above is only an excerpt.
for your institution. Subscribe
To learn more about subscribing to AccessScience, or to request a no-risk trial of this award-winning scientific reference for your institution, fill in your information and a member of our Sales Team will contact you as soon as possible.
to your librarian. Recommend
Let your librarian know about the award-winning gateway to the most trustworthy and accurate scientific information.
AccessScience provides the most accurate and trustworthy scientific information available.
Recognized as an award-winning gateway to scientific knowledge, AccessScience is an amazing online resource that contains high-quality reference material written specifically for students. Contributors include more than 9000 highly qualified scientists and 43 Nobel Prize winners.
MORE THAN 8700 articles covering all major scientific disciplines and encompassing the McGraw-Hill Encyclopedia of Science & Technology and McGraw-Hill Yearbook of Science & Technology
115,000-PLUS definitions from the McGraw-Hill Dictionary of Scientific and Technical Terms
3000 biographies of notable scientific figures
MORE THAN 19,000 downloadable images and animations illustrating key topics
ENGAGING VIDEOS highlighting the life and work of award-winning scientists
SUGGESTIONS FOR FURTHER STUDY and additional readings to guide students to deeper understanding and research
LINKS TO CITABLE LITERATURE help students expand their knowledge using primary sources of information