Campbell, William B. Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin.
Last reviewed:September 2021
- Biosynthesis and nomenclature
- Metabolites of cyclooxygenases
- Metabolites of lipoxygenases
- Metabolites of cytochrome P450
- Other pathways
- Physiological and pathological actions
- Mechanism of action
- Cyclooxygenase metabolites
- Lipoxygenase metabolites
- Cytochrome P450 metabolites
- Other pathways
- Related Primary Literature
- Additional Reading
A family of naturally occurring, biologically active substances derived from 20-carbon polyunsaturated fatty acids, such as arachidonic acid. Members of the eicosanoid family include prostaglandins, thromboxanes, leukotrienes, anandamide, and epoxyeicosatrienoic acids (EETs) [see illustration]. Functioning as local hormones, eicosanoids are synthesized and exert their biological actions in the same tissue. Many eicosanoids have physiological and pathological effects on the cardiovascular, pulmonary, reproductive, and digestive systems. See also: Biochemistry; Hormone
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