Effective dose 50
White, Colin Department of Epidemiology and Public Health, Yale University, New Haven, Connecticut.
- Additional Readings
This term is used chiefly to characterize the potency of a drug by the amount required to produce a response in 50% of the subjects to whom the drug is given. The term is also known as ED50 or median effective dose. At one time it was usual to try to measure the effect of a drug by noting the amount which was just sufficient to produce a particular response; but when it was realized that this amount varied greatly from subject to subject, attention was turned to measuring the effect on a group of subjects. Suppose, for example, that a drug is being used to relieve a certain type of pain; then the median effective dose is of such a size that it controls the pain in 50% of the sufferers and is insufficient to control it in the remaining 50%.
The content above is only an excerpt.
for your institution. Subscribe
To learn more about subscribing to AccessScience, or to request a no-risk trial of this award-winning scientific reference for your institution, fill in your information and a member of our Sales Team will contact you as soon as possible.
to your librarian. Recommend
Let your librarian know about the award-winning gateway to the most trustworthy and accurate scientific information.
AccessScience provides the most accurate and trustworthy scientific information available.
Recognized as an award-winning gateway to scientific knowledge, AccessScience is an amazing online resource that contains high-quality reference material written specifically for students. Contributors include more than 9000 highly qualified scientists and 43 Nobel Prize winners.
MORE THAN 8500 articles and Research Reviews covering all major scientific disciplines and encompassing the McGraw-Hill Encyclopedia of Science & Technology and McGraw-Hill Yearbook of Science & Technology
115,000-PLUS definitions from the McGraw-Hill Dictionary of Scientific and Technical Terms
3000 biographies of notable scientific figures
MORE THAN 19,000 downloadable images and animations illustrating key topics
ENGAGING VIDEOS highlighting the life and work of award-winning scientists
SUGGESTIONS FOR FURTHER STUDY and additional readings to guide students to deeper understanding and research
LINKS TO CITABLE LITERATURE help students expand their knowledge using primary sources of information