Karlson, Peter Institut für Physiologische Chemie, Philipps-Universität, Marburg, Germany.
Last reviewed:December 2019
- Related Primary Literature
- Additional Reading
The molting hormone of insects. It was isolated in crystalline form from the common silkworm (Bombyx mori) by A. Butenandt and P. Karlson in 1954 and its chemical structure was elucidated in 1965. It is a derivative of cholesterol and its structure can be described as 2β,3β,14α,22R,25-penta-hydroxy-Δ7-5β-cholestene-6-one. Shortly thereafter the molting hormone of crustaceans (crustecdysone) was isolated and identified as 20-hydroxy-ecdysone (Fig. 1). The sample compound was identified as one of the active compounds in B. mori extracts by P. Hocks and coworkers and H. Hoffmeister and coworkers proposed the name ecdysterone. A group of Japanese chemists, working on the isolation of steroids from plants, came across some similarities of the spectra of 20-hydroxy-ecdysone and their compounds inokosterone and isoinokosterone; the latter was identical with 20-hydroxy-ecdysone. Inokosterone carries the last hydroxy group in position 26 instead of 25, which reduces the biological activity by a factor of 10. Several other structurally related and biologically active steroids have been isolated from plant sources, including ecdysone, but nothing is known about a possible biological function of these steroids in plants. See also: Steroid
The content above is only an excerpt.
for your institution. Subscribe
To learn more about subscribing to AccessScience, or to request a no-risk trial of this award-winning scientific reference for your institution, fill in your information and a member of our Sales Team will contact you as soon as possible.
to your librarian. Recommend
Let your librarian know about the award-winning gateway to the most trustworthy and accurate scientific information.
AccessScience provides the most accurate and trustworthy scientific information available.
Recognized as an award-winning gateway to scientific knowledge, AccessScience is an amazing online resource that contains high-quality reference material written specifically for students. Contributors include more than 10,000 highly qualified scientists and 46 Nobel Prize winners.
MORE THAN 8700 articles covering all major scientific disciplines and encompassing the McGraw-Hill Encyclopedia of Science & Technology and McGraw-Hill Yearbook of Science & Technology
115,000-PLUS definitions from the McGraw-Hill Dictionary of Scientific and Technical Terms
3000 biographies of notable scientific figures
MORE THAN 19,000 downloadable images and animations illustrating key topics
ENGAGING VIDEOS highlighting the life and work of award-winning scientists
SUGGESTIONS FOR FURTHER STUDY and additional readings to guide students to deeper understanding and research
LINKS TO CITABLE LITERATURE help students expand their knowledge using primary sources of information