Mottet, N. Karle University Hospital, University of Washington, Seattle, Washington.
Quaife, Carol Department of Pathology, University of Washington, Seattle, Washington.
Van Loon, J. C. Department of Geology, University of Toronto, Ontario, Canada.
Last reviewed:January 2020
- Geochemical aspects
- Related Primary Literature
- Additional Reading
A deleterious set of responses which occurs at the subcellular level, stimulated by some injury, and which is often manifested in altered structure or functioning of the affected organism. The concept of disease has been changing as understanding of biological systems has increased. For centuries disease was described in terms of gross changes. Then a major revolution in biology occurred between 1840 and 1860, based largely on the improvement and application of the light microscope. It included the works of Jacob Shleiden and Theodore Schwann, who developed the concept referred to as the cell theory. This theory states that the basic structural and functional unit of all plant and animal life is the cell. R. C. Virchow was the central figure who applied the cell theory to the pathogenesis of human disease. He recognized that diseases were the product of the alteration of cell structure and function. See also: Cell (biology)
The content above is only an excerpt.
for your institution. Subscribe
To learn more about subscribing to AccessScience, or to request a no-risk trial of this award-winning scientific reference for your institution, fill in your information and a member of our Sales Team will contact you as soon as possible.
to your librarian. Recommend
Let your librarian know about the award-winning gateway to the most trustworthy and accurate scientific information.
AccessScience provides the most accurate and trustworthy scientific information available.
Recognized as an award-winning gateway to scientific knowledge, AccessScience is an amazing online resource that contains high-quality reference material written specifically for students. Contributors include more than 10,000 highly qualified scientists and 45 Nobel Prize winners.
MORE THAN 8700 articles covering all major scientific disciplines and encompassing the McGraw-Hill Encyclopedia of Science & Technology and McGraw-Hill Yearbook of Science & Technology
115,000-PLUS definitions from the McGraw-Hill Dictionary of Scientific and Technical Terms
3000 biographies of notable scientific figures
MORE THAN 19,000 downloadable images and animations illustrating key topics
ENGAGING VIDEOS highlighting the life and work of award-winning scientists
SUGGESTIONS FOR FURTHER STUDY and additional readings to guide students to deeper understanding and research
LINKS TO CITABLE LITERATURE help students expand their knowledge using primary sources of information