DISCLAIMER: This article is being kept online for historical purposes. Though accurate at last review, it is no longer being updated. The page may contain broken links or outdated information.
Meyer-Lindenberg, Andreas Central Institute of Mental Health, Mannheim, Germany.
Weinberger, Daniel R. Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute of Mental Health, Bethesda, Maryland.
- Molecular action
- Brain systems involved in DARPP-32 effects
- DARPP-32 and human cognition
- DARPP-32 and drugs of abuse
- DARPP-32 and schizophrenia
- DARPP-32 and depression
- Additional Reading
Dopamine- and cAMP-regulated phosphoprotein of molecular weight 32 kDa (usually known by its acronym, DARPP-32) is a master molecular regulator in neurons that receive the neurotransmitter dopamine. For over two decades, an intense research effort has demonstrated that DARPP-32 occupies a unique position as a central molecular control point, integrating multiple information streams that converge through a variety of neurotransmitters, neuromodulators, neuropeptides, and steroid hormones onto dopaminoceptive neurons. Since dopaminergic neurotransmission is critical for motivated behavior, working memory, and reward-related learning and is implicated in, among other conditions, schizophrenia, alcoholism, Parkinson's disease, and pathological gambling, DARPP-32 has received considerable attention not only in basic neuroscience, but also in studies of the pathogenesis of these disorders and as a promising target for innovative drug treatment in psychiatry. In addition, DARPP-32 is found in nonneuronal tissues and may have relevance for certain types of cancer.
The content above is only an excerpt.
for your institution. Subscribe
To learn more about subscribing to AccessScience, or to request a no-risk trial of this award-winning scientific reference for your institution, fill in your information and a member of our Sales Team will contact you as soon as possible.
to your librarian. Recommend
Let your librarian know about the award-winning gateway to the most trustworthy and accurate scientific information.
AccessScience provides the most accurate and trustworthy scientific information available.
Recognized as an award-winning gateway to scientific knowledge, AccessScience is an amazing online resource that contains high-quality reference material written specifically for students. Contributors include more than 10,000 highly qualified scientists and 46 Nobel Prize winners.
MORE THAN 8700 articles covering all major scientific disciplines and encompassing the McGraw-Hill Encyclopedia of Science & Technology and McGraw-Hill Yearbook of Science & Technology
115,000-PLUS definitions from the McGraw-Hill Dictionary of Scientific and Technical Terms
3000 biographies of notable scientific figures
MORE THAN 19,000 downloadable images and animations illustrating key topics
ENGAGING VIDEOS highlighting the life and work of award-winning scientists
SUGGESTIONS FOR FURTHER STUDY and additional readings to guide students to deeper understanding and research
LINKS TO CITABLE LITERATURE help students expand their knowledge using primary sources of information