Cholesteryl ester transfer protein (CETP)
McPherson, Ruth Division of Cardiology, University of Ottawa Heart Institute, Ottowa, Canada.
- Reverse cholesterol transport
- Regulation of CETP gene expression
- Genetic variation at the CETP gene locus
- Animal studies
- CETP inhibitors in treatment of low-HDL states
- CETP in direct clearance of HDL-derived cholesteryl ester (selective uptake)
- Links to Primary Literature
- Additional Readings
A 74-kilodalton (kDa) hydrophobic glycoprotein that plays a central role in human high-density lipoprotein (HDL) metabolism and reverse cholesterol transport. Cholesteryl ester transfer protein (CETP) mediates the exchange of neutral lipid (both heteroexchange, which is the net transfer of cholesteryl ester between lipoproteins in exchange for triglyceride, and homoexchange, which is the bidirectional transfer of the same lipid) between apolipoprotein (apo) A-I- and apoB-containing lipoproteins (Fig. 1). See also: Cholesterol; Lipid; Lipid metabolism; Lipoprotein
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