Bowser, Michael T. Department of Chemistry, University of Minnesota, Minneapolis, Minnesota.
- Selection of aptamers using CE-SELEX
- Links to Primary Literature
- Additional Readings
Every chemical reaction or biochemical pathway is influenced by how molecules interact with each other. Considering this, it is not surprising that isolating ligands with high affinity and specificity for particular receptors is an area of intense research. Ligands for biological receptors could make excellent drug candidates. High-specificity ligands can be used to develop assays for biological, environmental, or industrial analytes of interest. Traditionally, ligands have been discovered using rational molecular design or random combinatorial methods. Both are notoriously labor-intensive processes. SELEX (systematic evolution of ligands through exponential enrichment) provides an alternative approach that uses molecular evolution to isolate high-affinity/selectivity ligands. SELEX can be simplified and shortened by incorporating capillary electrophoresis (CE) selection into the process.
The content above is only an excerpt.
for your institution. Subscribe
To learn more about subscribing to AccessScience, or to request a no-risk trial of this award-winning scientific reference for your institution, fill in your information and a member of our Sales Team will contact you as soon as possible.
to your librarian. Recommend
Let your librarian know about the award-winning gateway to the most trustworthy and accurate scientific information.
AccessScience provides the most accurate and trustworthy scientific information available.
Recognized as an award-winning gateway to scientific knowledge, AccessScience is an amazing online resource that contains high-quality reference material written specifically for students. Contributors include more than 9000 highly qualified scientists and 43 Nobel Prize winners.
MORE THAN 8500 articles and Research Reviews covering all major scientific disciplines and encompassing the McGraw-Hill Encyclopedia of Science & Technology and McGraw-Hill Yearbook of Science & Technology
115,000-PLUS definitions from the McGraw-Hill Dictionary of Scientific and Technical Terms
3000 biographies of notable scientific figures
MORE THAN 19,000 downloadable images and animations illustrating key topics
ENGAGING VIDEOS highlighting the life and work of award-winning scientists
SUGGESTIONS FOR FURTHER STUDY and additional readings to guide students to deeper understanding and research
LINKS TO CITABLE LITERATURE help students expand their knowledge using primary sources of information