Beutler, Bruce A. Center for Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, Texas. Nobelist.
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The severe wasting syndrome that accompanies such diseases as cancer, infection, or parasitic infestation. Occasionally, it is also observed in noninvasive conditions, such as severe cardiac failure. The causes of cachexia are only partially understood. However, it is clear that most cachexia is caused by diminished consumption of nutrients rather than by a hypermetabolic state.
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